My road to Damascus: how I converted to the prohormone theory and the proprotein convertases. (Q48345564)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1

Michel Chrétien

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10 February 2018

http://europepmc.org/abstract/MED/23194189

publication date

8 November 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

Biochemistry and Cell Biology

19 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

90

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

6

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19 February 2020

page(s)

750-768

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

19 February 2020

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

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Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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Biomedicine. Lowering LDL--not only how low, but how long?

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Effects of glacial acetic acid on the extraction, chemical stability, and biological activities of beta-LPH.

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Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia

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Radioimmunoassay of ovine beta-lipotropic hormone

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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

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A new method for measurement of total plasma PCSK9: clinical applications

21 January 2018

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Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue

21 January 2018

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High molecular weight forms of adrenocorticotropic hormone in the mouse pituitary and in a mouse pituitary tumor cell line

21 January 2018

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Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

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Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

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Intracellular targeting and structural conservation of a prohormone-processing endoprotease

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

21 January 2018

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Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

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PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.

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Peptides in the Brain: The New Endocrinology of the Neuron

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Biosynthesis of polyprotein precursors to regulatory peptides

21 January 2018

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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

21 January 2018

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PCSK9: a convertase that coordinates LDL catabolism

21 January 2018

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Identification of two related pentapeptides from the brain with potent opiate agonist activity

21 January 2018

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

21 January 2018

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Lipotropin: localization by radioimmunoassay of endorphin precursors in pituitary and brain

21 January 2018

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beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins

21 January 2018

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Proteases and posttranslational processing of prohormones: a review

21 January 2018

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Commentary PCSK9 variants: A new database

21 January 2018

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Common low-density lipoprotein receptor mutations in the French Canadian population

21 January 2018

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LIPOTROPIN, A NEW ACTIVE PEPTIDE FROM PITUITARY GLANDS.

21 January 2018

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Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

21 January 2018

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Common precursor to corticotropins and endorphins

21 January 2018

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

21 January 2018

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Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture

21 January 2018

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Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human

21 January 2018

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

21 January 2018

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Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction

21 January 2018

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Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

21 January 2018

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Genomics of Cardiovascular Disease

21 January 2018

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Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

21 January 2018

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Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

21 January 2018

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Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland

21 January 2018

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

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Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule

21 January 2018

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Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system

21 January 2018

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Insertion of a rabbit beta-globin gene sequence into an E. coli plasmid

21 January 2018

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Proprotein convertases: lessons from knockouts

21 January 2018

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Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

21 January 2018

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The proprotein convertases, 20 years later

21 January 2018

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Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

21 January 2018

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The biology and therapeutic targeting of the proprotein convertases

21 January 2018

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In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia

21 January 2018

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Homologous IRCM-serine protease 1 from pituitary, heart atrium and ventricle: a common pro-hormone maturation enzyme?

21 January 2018

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The cDNA structure of rat plasma kallikrein

21 January 2018

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cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

21 January 2018

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Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

21 January 2018

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Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

21 January 2018

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

21 January 2018

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

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The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

21 January 2018

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Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

21 January 2018

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Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

21 January 2018

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Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

21 January 2018

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The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma

21 January 2018

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Insulin biosynthesis: evidence for a precursor

21 January 2018

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Curbing activation: proprotein convertases in homeostasis and pathology

21 January 2018

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

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Rare cell proteomic reactor applied to stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics study of human embryonic stem cell differentiation.

21 January 2018

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Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

21 January 2018

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Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

21 January 2018

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Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

21 January 2018

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The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain

21 January 2018

1 reference

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

21 January 2018

1 reference

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

21 January 2018

1 reference

Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides

21 January 2018

1 reference

A novel human pituitary peptide containing the γ-MSH sequence

21 January 2018

1 reference

Assignment of the gene for neuroendocrine protein 7B2 (SGNE1 locus) to mouse chromosome region 2[E3–F3] and to human chromosome region 15q11-q15

21 January 2018

1 reference

Plasma PCSK9 levels correlate with cholesterol in men but not in women

21 January 2018

1 reference

PCSK9 as a therapeutic target of dyslipidemia

21 January 2018

1 reference

Isolation and Amino-acid Sequence of β-LPH from Sheep Pituitary Glands

21 January 2018

1 reference

IDENTIFICATION OF SMALL AMOUNTS OF ORGANIC COMPOUNDS BY DISTRIBUTION STUDIES

21 January 2018

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(17)41546-8

Identifiers

DOI

10.1139/O2012-031

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23194189%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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