The biology and therapeutic targeting of the proprotein convertases (Q38017196)

27 August 2017

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The biology and therapeutic targeting of the proprotein convertases (English)

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27 August 2017

Annik Prat

2

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Nabil Seidah

object named as

Nabil G Seidah

series ordinal

1

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publication date

1 May 2012

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Nature Reviews Drug Discovery

27 August 2017

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27 August 2017

11

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27 August 2017

367-383

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27 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd3699

27 August 2017

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cites work

Human and mouse proteases: a comparative genomic approach

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The metabolic serine hydrolases and their functions in mammalian physiology and disease

31 March 2020

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Subtilases: the superfamily of subtilisin-like serine proteases

31 March 2020

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Structure of Subtilisin BPN′ at 2.5 Å Resolution

31 March 2020

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MEROPS: the peptidase database

31 March 2020

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Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease

31 March 2020

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The proprotein convertases, 20 years later

31 March 2020

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Proprotein convertases in health and disease

31 March 2020

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Knock-out mouse models of proprotein convertases: unique functions or redundancy?

31 March 2020

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The activation and physiological functions of the proprotein convertases

31 March 2020

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What lies ahead for the proprotein convertases?

31 March 2020

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The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.

31 March 2020

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

31 March 2020

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

31 March 2020

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Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

1 reference

Site-1 protease is essential for endochondral bone formation in mice.

31 March 2020

1 reference

Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization

31 March 2020

1 reference

SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

31 March 2020

1 reference

A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism

31 March 2020

1 reference

The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

31 March 2020

1 reference

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

31 March 2020

1 reference

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

31 March 2020

1 reference

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

31 March 2020

1 reference

The proprotein convertases

31 March 2020

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The proprotein convertases are potential targets in the treatment of dyslipidemia

31 March 2020

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Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

31 March 2020

1 reference

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

31 March 2020

1 reference

PCSK9 as a therapeutic target of dyslipidemia

31 March 2020

1 reference

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

31 March 2020

1 reference

Identification of proprotein convertase substrates using genome-wide expression correlation analysis.

31 March 2020

1 reference

The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors

31 March 2020

1 reference

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

31 March 2020

1 reference

Functional characterization of Narc 1, a novel proteinase related to proteinase K

31 March 2020

1 reference

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

31 March 2020

1 reference

Molecular biology of PCSK9: its role in LDL metabolism

31 March 2020

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PCSK9: a convertase that coordinates LDL catabolism

31 March 2020

1 reference

Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

31 March 2020

1 reference

Neuroendocrine secretory protein 7B2: structure, expression and functions

31 March 2020

1 reference

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

31 March 2020

1 reference

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

31 March 2020

1 reference

Enzymic characterization in vitro of recombinant proprotein convertase PC4.

31 March 2020

1 reference

The proprotein convertase PC7: unique zymogen activation and trafficking pathways

31 March 2020

1 reference

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

31 March 2020

1 reference

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

31 March 2020

1 reference

Furin at the cutting edge: from protein traffic to embryogenesis and disease

31 March 2020

1 reference

Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells

31 March 2020

1 reference

Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability

31 March 2020

1 reference

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.

31 March 2020

1 reference

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

31 March 2020

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Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

31 March 2020

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

31 March 2020

1 reference

Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.

31 March 2020

1 reference

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

31 March 2020

1 reference

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

31 March 2020

1 reference

Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix

31 March 2020

1 reference

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

31 March 2020

1 reference

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

31 March 2020

1 reference

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

31 March 2020

1 reference

PC8 [corrected], a new member of the convertase family

31 March 2020

1 reference

Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase

31 March 2020

1 reference

The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments

31 March 2020

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Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif

31 March 2020

1 reference

The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.

31 March 2020

1 reference

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

31 March 2020

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

31 March 2020

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The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

31 March 2020

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Molecular basis for LDL receptor recognition by PCSK9

31 March 2020

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Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

31 March 2020

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A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9.

31 March 2020

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Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain

31 March 2020

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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

31 March 2020

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Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

31 March 2020

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Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis

31 March 2020

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Nucleotide sequence analysis of the human fur gene

31 March 2020

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Host cell proteases controlling virus pathogenicity

31 March 2020

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Understanding influenza virus pathogenicity

31 March 2020

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Maturation of HIV envelope glycoprotein precursors by cellular endoproteases

31 March 2020

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The role of furin in papillomavirus infection

31 March 2020

1 reference

Anthrax toxin: receptor binding, internalization, pore formation, and translocation

31 March 2020

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Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain

31 March 2020

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Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

31 March 2020

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In vivo evidence that furin from hepatocytes inactivates PCSK9

31 March 2020

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Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

31 March 2020

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

31 March 2020

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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

31 March 2020

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Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity

31 March 2020

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In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.

31 March 2020

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In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate

31 March 2020

1 reference

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

31 March 2020

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ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

31 March 2020

1 reference

Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases

31 March 2020

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Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

31 March 2020

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Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor

31 March 2020

1 reference

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels

31 March 2020

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Protein sensors for membrane sterols

31 March 2020

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Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6.

31 March 2020

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Precursor convertases in the secretory pathway, cytosol and extracellular milieu

31 March 2020

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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

31 March 2020

1 reference

PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression

31 March 2020

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A new method for measurement of total plasma PCSK9: clinical applications

31 March 2020

1 reference

Proprotein convertases: lessons from knockouts

31 March 2020

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The proprotein convertases and their implication in sterol and/or lipid metabolism

31 March 2020

1 reference

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

31 March 2020

1 reference

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice

31 March 2020

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Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone

31 March 2020

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Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.

31 March 2020

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Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

31 March 2020

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

31 March 2020

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Defective prodynorphin processing in mice lacking prohormone convertase PC2.

31 March 2020

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Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

31 March 2020

1 reference

Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.

31 March 2020

1 reference

The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

31 March 2020

1 reference

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

31 March 2020

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Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

31 March 2020

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Common nonsynonymous variants in PCSK1 confer risk of obesity

31 March 2020

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31 March 2020

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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

31 March 2020

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Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.

31 March 2020

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Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

31 March 2020

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BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

31 March 2020

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Limited redundancy of the proprotein convertase furin in mouse liver

31 March 2020

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Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate

31 March 2020

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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

31 March 2020

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

31 March 2020

1 reference

Prohormone convertase PC4 processes the precursor of PACAP in the testis

31 March 2020

2 references

31 March 2020

12 December 2020

Role of pro-IGF-II processing by proprotein convertase 4 in human placental development

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Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

31 March 2020

1 reference

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy

31 March 2020

1 reference

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels

31 March 2020

1 reference

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

31 March 2020

1 reference

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

31 March 2020

1 reference

PCSK6 is associated with handedness in individuals with dyslexia

31 March 2020

1 reference

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

31 March 2020

1 reference

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

31 March 2020

1 reference

Functional analysis of secreted and transmembrane proteins critical to mouse development.

31 March 2020

1 reference

Site-1 protease is required for cartilage development in zebrafish

31 March 2020

1 reference

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

31 March 2020

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Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice

31 March 2020

1 reference

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

31 March 2020

1 reference

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

31 March 2020

1 reference

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

31 March 2020

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Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.

31 March 2020

1 reference

A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

31 March 2020

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

31 March 2020

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

31 March 2020

1 reference

Proprotein convertases: "master switches" in the regulation of tumor growth and progression

31 March 2020

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Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

31 March 2020

1 reference

On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

31 March 2020

1 reference

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

31 March 2020

1 reference

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

31 March 2020

1 reference

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

31 March 2020

1 reference

Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis

31 March 2020

1 reference

Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

31 March 2020

1 reference

Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules

31 March 2020

1 reference

A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness

31 March 2020

1 reference

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics

31 March 2020

1 reference

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

31 March 2020

1 reference

In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates.

31 March 2020

1 reference

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

31 March 2020

1 reference

Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer

31 March 2020

1 reference

Dendritic cells: understanding immunogenicity

31 March 2020

1 reference

Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion

31 March 2020

1 reference

Molecular Validation of PACE4 as a Target in Prostate Cancer

31 March 2020

1 reference

Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.

31 March 2020

1 reference

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein

31 March 2020

1 reference

Proprotein convertase activation of aggrecanases in cartilage in situ.

31 March 2020

1 reference

Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

31 March 2020

1 reference

Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions

31 March 2020

1 reference

Synthetic small-molecule prohormone convertase 2 inhibitors

31 March 2020

1 reference

Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives

31 March 2020

1 reference

Proprotein convertase inhibitory activities of flavonoids isolated from Oroxylum indicum

31 March 2020

1 reference

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein

31 March 2020

1 reference

Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals

31 March 2020

1 reference

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease

31 March 2020

1 reference

Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells

31 March 2020

1 reference

Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242.

31 March 2020

1 reference

Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents

31 March 2020

1 reference

Computational reverse-engineering of a spider-venom derived peptide active against Plasmodium falciparum SUB1

31 March 2020

1 reference

PCSK9: an emerging target for treatment of hypercholesterolemia

31 March 2020

1 reference

Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents

31 March 2020

1 reference

Clinical aspects of PCSK9.

31 March 2020

1 reference

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial

31 March 2020

1 reference

Neurodegenerative disease: Novel ALS therapy shows promise in Phase II

31 March 2020

1 reference

The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis

31 March 2020

1 reference

Genetic and metabolic determinants of plasma PCSK9 levels

31 March 2020

1 reference

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

31 March 2020

1 reference

Dual regulation of the LDL receptor--some clarity and new questions

31 March 2020

1 reference

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort

31 March 2020

1 reference

Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

31 March 2020

1 reference

Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy.

31 March 2020

1 reference

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

31 March 2020

1 reference

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

31 March 2020

1 reference

Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates

31 March 2020

1 reference

A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

31 March 2020

1 reference

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

31 March 2020

1 reference

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

31 March 2020

1 reference

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

31 March 2020

1 reference

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates

31 March 2020

1 reference

Proprotein convertases as therapeutic targets

31 March 2020

1 reference

Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

31 March 2020

1 reference

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

31 March 2020

1 reference

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease.

31 March 2020

1 reference

Associations between genetic variations in the FURIN gene and hypertension

31 March 2020

1 reference

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

31 March 2020

1 reference

Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension

31 March 2020

1 reference

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

31 March 2020

1 reference

Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addict

31 March 2020

1 reference

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

31 March 2020

1 reference

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

31 March 2020

1 reference

The Pore-forming Toxin Proaerolysin Is Activated by Furin

31 March 2020

1 reference

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

31 March 2020

1 reference

Pro-protein convertases of subtilisin/kexin family.

31 March 2020

1 reference

On the discovery of precursor processing

31 March 2020

1 reference

The prohormone theory and the proprotein convertases: it is all about serendipity

31 March 2020

1 reference

Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases

31 March 2020

1 reference

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor

31 March 2020

1 reference

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

31 March 2020

1 reference

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

31 March 2020

1 reference

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

31 March 2020

1 reference

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

31 March 2020

1 reference

Commentary PCSK9 variants: A new database

31 March 2020

1 reference

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

31 March 2020

1 reference

Effect of a monoclonal antibody to PCSK9 on LDL cholesterol

31 March 2020

1 reference

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

31 March 2020

1 reference

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

31 March 2020

1 reference

12 December 2020

Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics

1 reference

12 December 2020

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas

1 reference

12 December 2020

A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.

1 reference

12 December 2020

'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus

1 reference

12 December 2020

MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice

1 reference

12 December 2020

Trial watch: PCSK9 antibody reduces LDL cholesterol

1 reference

12 December 2020

Statin therapy for prevention and treatment of acute and chronic cardiovascular disease: update on recent trials and metaanalyses

1 reference

12 December 2020

Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

1 reference

12 December 2020

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

1 reference

12 December 2020

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

1 reference

12 December 2020

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1 reference

12 December 2020

Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

1 reference

12 December 2020

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

1 reference

12 December 2020

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

1 reference

12 December 2020

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase

1 reference

12 December 2020

Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.

1 reference

12 December 2020

Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary.

1 reference

12 December 2020

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

1 reference

12 December 2020

Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3699

1 reference

PubMed ID

22679642

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22679642