Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. (Q48354251)

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scientific article published on 13 January 2017

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English	Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.	scientific article published on 13 January 2017

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9 April 2020

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment (English)

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9 April 2020

Andreas Strasser

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9 April 2020

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9 April 2020

Susanne Heinzel

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9 April 2020

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Emma M Carrington

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9 April 2020

Charis E Teh

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9 April 2020

Lin Tai

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9 April 2020

Andreas Villunger

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9 April 2020

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13 January 2017

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9 April 2020

Cell Death & Differentiation

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9 April 2020

534-545

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9 April 2020

https://scigraph.springernature.com/pub.10.1038/cdd.2016.156

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The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

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The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

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Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

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Gene expression profiling of Mycobacterium tuberculosis Lipoarabinomannan-treated macrophages: A role of the Bcl-2 family member A1 in inhibition of apoptosis in mycobacteria-infected macrophages

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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

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Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis

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18 June 2018

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

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Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

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Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

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Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

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18 June 2018

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

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Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines

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Mcl-1 is essential for the survival of plasma cells

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18 June 2018

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

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A1/Bfl-1 in leukocyte development and cell death

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18 June 2018

BCL2A1: the underdog in the BCL2 family

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18 June 2018

Mcl-1 is essential for germinal center formation and B cell memory

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Programmed anuclear cell death delimits platelet life span.

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18 June 2018

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

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18 June 2018

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

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Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

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Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly

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Apoptosis signaling

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18 June 2018

A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor

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18 June 2018

Mcl-1 deficiency results in peri-implantation embryonic lethality

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18 June 2018

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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18 June 2018

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

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Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

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Multiple gene duplication and expression of mouse bcl-2-related genes, A1.

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Testicular degeneration in Bclw-deficient mice

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18 June 2018

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

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18 June 2018

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

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Characterisation of a novel A1-specific monoclonal antibody.

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Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

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14 August 2018

Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection.

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

1 reference

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14 August 2018

Regulation of A1/Bfl-1 expression in peripheral splenic B cells

1 reference

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14 August 2018

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

1 reference

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14 August 2018

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

1 reference

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14 August 2018

A1/Bfl-1 expression is restricted to TCR engagement in T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

21 January 2018

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

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A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2016.156

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDD.2016.156

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9 April 2020

PMC publication ID

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9 April 2020

PubMed publication ID

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9 April 2020

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