The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy. (Q48382639)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28017471%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy (English)

1 reference

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2 April 2020

main subject

spinal muscular atrophy

1 reference

4

1 reference

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2 April 2020

Lee L. Rubin

10

1 reference

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2 April 2020

author name string

Constantin d'Ydewalle

1

1 reference

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2 April 2020

Daniel M Ramos

2

1 reference

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2 April 2020

Noah J Pyles

3

1 reference

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2 April 2020

Mariusz Gorz

5

1 reference

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2 April 2020

Celeste M Pilato

6

1 reference

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2 April 2020

Karen Ling

7

1 reference

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2 April 2020

Lingling Kong

8

1 reference

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2 April 2020

Amanda J Ward

9

1 reference

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2 April 2020

Frank Rigo

11

1 reference

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2 April 2020

C Frank Bennett

12

1 reference

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2 April 2020

Charlotte J Sumner

13

1 reference

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2 April 2020

language of work or name

English

0 references

publication date

22 December 2016

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2 April 2020

1 reference

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2 April 2020

volume

93

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2 April 2020

issue

1

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2 April 2020

page(s)

66-79

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Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus

2 April 2020

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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RNA learns from antisense

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22 May 2018

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22 May 2018

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A slow RNA polymerase II affects alternative splicing in vivo

22 May 2018

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The future of antisense therapy: combination with anticancer treatments

22 May 2018

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Role of histone H3 lysine 27 methylation in X inactivation

22 May 2018

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Genome imprinting regulated by the mouse Polycomb group protein Eed

22 May 2018

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

22 May 2018

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

22 May 2018

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A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome

22 May 2018

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A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Promoter analysis of the human centromeric and telomeric survival motor neuron genes (SMNC and SMNT).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

The promoters of the survival motor neuron gene (SMN) and its copy (SMNc) share common regulatory elements

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Expression of the SMN gene, the spinal muscular atrophy determining gene, in the mammalian central nervous system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Identification and characterization of a spinal muscular atrophy-determining gene

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Increasing SMN levels using the histone deacetylase inhibitor SAHA ameliorates defects in skeletal muscle microvasculature in a mouse model of severe spinal muscular atrophy

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Argonaute proteins couple chromatin silencing to alternative splicing.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy-like mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Survival motor neuron SMN1 and SMN2 gene promoters: identical sequences and differential expression in neurons and non-neuronal cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

The Prader-Willi syndrome imprinting center activates the paternally expressed murine Ube3a antisense transcript but represses paternal Ube3a

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5223741

Antitumor Efficacy of bcl-2 and c-myc Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence

14 August 2018

1 reference

12 December 2020

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

1 reference

12 December 2020

Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury

1 reference

12 December 2020

The distribution of SMN protein complex in human fetal tissues and its alteration in spinal muscular atrophy

1 reference

12 December 2020

10.1016/J.NEURON.2016.11.033

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28017471%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28017471%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

28017471

1 reference