Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain (Q48535363)

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scientific article published on 3 May 2012

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English	Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain	scientific article published on 3 May 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

author name string

Jianhua Wu

1

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Jianzhe Li

2

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Hankun Hu

3

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Ping Liu

4

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Yunxiang Fang

5

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Dongfang Wu

6

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

publication date

3 May 2012

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Cellular and Molecular Neurobiology

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

32

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

7

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

1187-1197

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

Regulation and functions of Rho-associated kinase

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Apoptotic mechanisms after cerebral ischemia

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Future targets and cascades for neuroprotective strategies.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

PI3K/Akt and apoptosis: size matters

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Rho kinase inhibition protects CA1 cells in organotypic hippocampal slices during in vitro ischemia

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Regulation of PTEN by Rho small GTPases

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Rho kinase in the regulation of cell death and survival

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1

1 reference

https://api.crossref.org/works/10.1007%2FS10571-012-9845-Z

21 January 2018

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22552888

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/22552888

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22552888

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10571-012-9845-Z

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22552888

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