The reverse stop-signal model for CTLA4 function. (Q48540784)

12 February 2018

review article

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title

The reverse stop-signal model for CTLA4 function. (English)

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12 February 2018

author name string

Christopher E Rudd

series ordinal

1

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12 February 2018

publication date

1 February 2008

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12 February 2018

Nature Reviews Immunology

published in

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12 February 2018

volume

8

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12 February 2018

issue

2

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12 February 2018

page(s)

153-160

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12 February 2018

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

cites work

1 reference

The role of CTLA-4 in the regulation and initiation of T-cell responses

31 March 2020

1 reference

T cell tolerance and autoimmunity

31 March 2020

1 reference

Negative co-receptors on lymphocytes

31 March 2020

1 reference

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

31 March 2020

1 reference

T-cell regulation by CD28 and CTLA-4.

31 March 2020

1 reference

Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling

31 March 2020

1 reference

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

31 March 2020

1 reference

CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

31 March 2020

1 reference

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

31 March 2020

1 reference

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

31 March 2020

1 reference

T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.

31 March 2020

1 reference

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

31 March 2020

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Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

31 March 2020

1 reference

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

31 March 2020

1 reference

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

31 March 2020

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Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

31 March 2020

1 reference

Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice

31 March 2020

1 reference

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

1 reference

Modeling CTLA4-linked autoimmunity with RNA interference in mice

31 March 2020

1 reference

Emerging challenges in regulatory T cell function and biology

31 March 2020

1 reference

An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

1 reference

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

31 March 2020

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Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

31 March 2020

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Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

31 March 2020

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Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.

31 March 2020

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Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.

31 March 2020

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

31 March 2020

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CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

31 March 2020

1 reference

CTLA-4 can function as a negative regulator of T cell activation

31 March 2020

1 reference

CTLA-4 blockade of antigen-induced cell death

31 March 2020

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Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo

31 March 2020

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Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor

31 March 2020

1 reference

Structural analysis of CTLA-4 function in vivo

31 March 2020

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CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism

31 March 2020

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Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation

31 March 2020

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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

31 March 2020

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

31 March 2020

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B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

31 March 2020

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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

31 March 2020

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Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice

31 March 2020

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B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

31 March 2020

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Molecular basis of T cell inactivation by CTLA-4

31 March 2020

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Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

31 March 2020

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A molecular perspective of CTLA-4 function

31 March 2020

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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

31 March 2020

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Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice

31 March 2020

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Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function

31 March 2020

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The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

31 March 2020

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Costimulatory regulation of T cell function.

31 March 2020

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Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation

31 March 2020

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Cbl-b regulates the CD28 dependence of T-cell activation.

31 March 2020

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

31 March 2020

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Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

31 March 2020

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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T lymphocyte costimulation mediated by reorganization of membrane microdomains

31 March 2020

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

31 March 2020

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

31 March 2020

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CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

31 March 2020

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CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

31 March 2020

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CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

31 March 2020

1 reference

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

31 March 2020

1 reference

Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.

31 March 2020

1 reference

CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase

31 March 2020

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Reversal of the TCR stop signal by CTLA-4

31 March 2020

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Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.

31 March 2020

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Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

31 March 2020

1 reference

Two-photon imaging of lymphocyte motility and antigen response in intact lymph node

31 March 2020

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Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

31 March 2020

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CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.

31 March 2020

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Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo

31 March 2020

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In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance.

31 March 2020

1 reference

A cell culture model for T lymphocyte clonal anergy

31 March 2020

1 reference

T-cell integrins: more than just sticking points

31 March 2020

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Membranes as messengers in T cell adhesion signaling

31 March 2020

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TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice

31 March 2020

1 reference

The B7 family and cancer therapy: costimulation and coinhibition

31 March 2020

1 reference

B7-independent inhibition of T cells by CTLA-4.

31 March 2020

1 reference

Stop and go traffic to tune T cell responses

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2253

1 reference

12 February 2018

release_xkidc6uojva6pbuixxwpdzlpt4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xkidc6uojva6pbuixxwpdzlpt4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

18219311

1 reference

12 February 2018