Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. (Q48546153)

http://europepmc.org/abstract/MED/16687499

12 February 2018

title

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674262&resulttype=core&format=json

11 May 2020

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4

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11 May 2020

Tobias Engel

series ordinal

1

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11 May 2020

Felix Hernandez

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674262&resulttype=core&format=json

11 May 2020

author name string

Jesús Avila

series ordinal

3

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11 May 2020

language of work or name

English

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publication date

1 May 2006

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http://europepmc.org/abstract/MED/16687499

12 February 2018

published in

Journal of Neuroscience

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11 May 2020

volume

26

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11 May 2020

issue

19

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11 May 2020

page(s)

5083-5090

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Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

11 May 2020

cites work

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12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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Binding specificity of monoclonal antibody AD2: influence of the phosphorylation state of tau.

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Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

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Huntington's disease: the challenge for cell biologists

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

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GSK-3 and the neurodevelopmental hypothesis of schizophrenia

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Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

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Glycogen synthase kinase 3: an emerging therapeutic target

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12 December 2020

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

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Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways

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Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

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Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

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Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.

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Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology

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Comparison of the sedimentation properties of microtubule protein oligomers prepared by two different procedures

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

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12 December 2020

Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.

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Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790.

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Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

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Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

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Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

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Divergent roles of GSK3 and CDK5 in APP processing

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Role of tau protein in both physiological and pathological conditions.

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The glamour and gloom of glycogen synthase kinase-3

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GSK3 inhibitors: development and therapeutic potential

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Glycogen synthase kinase 3: a drug target for CNS therapies

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

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12 December 2020

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

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12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

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12 December 2020

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

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12 December 2020

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

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12 December 2020

A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons

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12 December 2020

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

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12 December 2020

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

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12 December 2020

Molecular cloning and expression of glycogen synthase kinase-3/factor A

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12 December 2020

Microtubule Assembly in the Absence of Added Nucleotides

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12 December 2020

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

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12 December 2020

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

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12 December 2020

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

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12 December 2020

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

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12 December 2020

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

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12 December 2020

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

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12 December 2020

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

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12 December 2020

Functional studies of Alzheimer's disease tau protein.

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12 December 2020

A molecular mechanism for the effect of lithium on development

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12 December 2020

Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta

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12 December 2020

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

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12 December 2020

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

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12 December 2020

Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.

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12 December 2020

Glycogen synthase kinase 3 phosphorylation of different residues in the presence of different factors: analysis on tau protein.

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12 December 2020

Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix.

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12 December 2020

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

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12 December 2020

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

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12 December 2020

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

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12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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12 December 2020

Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase

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12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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12 December 2020

Genetic neurodegenerative diseases: the human illness and transgenic models

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12 December 2020

10.1523/JNEUROSCI.0604-06.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674262&resulttype=core&format=json

11 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674262&resulttype=core&format=json

11 May 2020

1 reference