Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics (Q48812098)

15 February 2018

title

Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics (English)

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15 February 2018

author name string

Heidrun Appl

1

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15 February 2018

Tobias Holzammer

2

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15 February 2018

Stefan Dove

3

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15 February 2018

Ekkehard Haen

4

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15 February 2018

Andrea Strasser

5

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15 February 2018

Roland Seifert

6

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15 February 2018

publication date

28 October 2011

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15 February 2018

Naunyn-Schmiedeberg's Archives of Pharmacology

published in

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15 February 2018

volume

385

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15 February 2018

issue

2

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15 February 2018

page(s)

145-170

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15 February 2018

Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation

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Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.

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Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors

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Tricyclic antidepressant drugs block histamine H2 receptor in brain

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Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry

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Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment

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Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations

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No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatment

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CSF concentrations of famotidine

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Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue

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Brain histamine receptors as targets for antidepressant drugs

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Predicting new molecular targets for known drugs

21 January 2018

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Functional selectivity and biased receptor signaling

21 January 2018

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Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells

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Conformational complexity of G-protein-coupled receptors

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H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

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Clozapine is cytotoxic to primary cultures of human bone marrow mesenchymal stromal cells.

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En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family

21 January 2018

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Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

21 January 2018

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Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors

21 January 2018

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Molecular determinants of ligand binding to H4R species variants

21 January 2018

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Agranulocytosis associated with initiation of famotidine therapy

21 January 2018

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Histamine-induced differentiation of HL-60 cells. The role of cAMP and protein kinase A

21 January 2018

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Haematological toxicity of clozapine and some other drugs used in psychiatry.

21 January 2018

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Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis.

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21 January 2018

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Modulation of histamine H(3) receptor function by monovalent ions

21 January 2018

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No evidence for functional selectivity of proxyfan at the human histamine H3 receptor coupled to defined Gi/Go protein heterotrimers

21 January 2018

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Comparison of the pharmacological properties of human and rat histamine H3-receptors

21 January 2018

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Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.

21 January 2018

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Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

21 January 2018

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Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein

21 January 2018

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Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor

21 January 2018

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Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity.

21 January 2018

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Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta2 adrenergic receptor template

21 January 2018

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Structure of the human histamine H1 receptor complex with doxepin

21 January 2018

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Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms

21 January 2018

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Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor

21 January 2018

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Impact of fusion to Gα(i2) and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB₁R and CB₂R.

21 January 2018

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Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward: a study of receptors gene knockout mice.

21 January 2018

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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

21 January 2018

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Histamine H3 and H4 receptors as novel drug targets.

21 January 2018

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Pharmacological characterization and autoradiographic localization of histamine H2 receptors in human brain identified with [125I]iodoaminopotentidine.

21 January 2018

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Mutational analysis of the antagonist-binding site of the histamine H(1) receptor

21 January 2018

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N (α)-Methylated phenylhistamines exhibit affinity to the hH(4)R-a pharmacological and molecular modelling study

21 January 2018

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Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions

21 January 2018

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12 December 2020

Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists.

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Cimetidine and Psychiatric Complications

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The function of histamine receptor H4R in the brain revealed by interaction partners

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Depression Associated with Cimetidine

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12 December 2020

Molecular basis for the interaction of histamine with the histamine H2 receptor

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Tricyclic Antidepressant Therapy for Peptic Ulcer Disease

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Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.

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Case Report: Cimetidine-Associated Depression and Loss of Libido in a Woman

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Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice

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Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics.

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Clozapine versus other atypical antipsychotics for schizophrenia

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Treatment of duodenal ulcer with antacids in combination with trimipramine or cimetidine.

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Clozapine serum levels and side effects during steady state treatment of schizophrenic patients: a cross-sectional study

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Monovalent anions differentially modulate coupling of the beta2-adrenoceptor to G(s)alpha splice variants

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Individuals with schizophrenia have an increased incidence of the H2R649G allele for the histamine H2 receptor gene.

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12 December 2020

Identification and characterization of surface receptors for histamine in the human promyelocytic leukemia cell line HL-60. Comparison with human peripheral neutrophils

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Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.

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Pharmacology of antidepressants in use in the United States

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12 December 2020

Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation

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12 December 2020

Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex.

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12 December 2020

Effects of some polycyclic drugs on gastric secretion and on the healing of duodenal ulcers

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12 December 2020

CSF concentrations of ranitidine

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12 December 2020

International Union of Pharmacology. XIII. Classification of histamine receptors

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12 December 2020

Histamine H2 receptor gene variants: lack of association with schizophrenia

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12 December 2020

Famotidine as an adjunct treatment of resistant schizophrenia.

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12 December 2020

Effect of famotidine on deficit symptoms of schizophrenia

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12 December 2020

Depression not associated with cimetidine

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12 December 2020

Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors

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Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.

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12 December 2020

Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation

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12 December 2020

Site-directed mutagenesis of the histamine H1 receptor: roles of aspartic acid107, asparagine198 and threonine194

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12 December 2020

10.1007/S00210-011-0704-0

Identifiers

DOI

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15 February 2018

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15 February 2018