Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease. (Q48959453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27775078%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease (English)

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26 March 2020

2

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26 March 2020

Madelon M Maurice

9

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26 March 2020

author name string

H van Andel

1

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26 March 2020

A de Haan-Kramer

3

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26 March 2020

C H Mellink

4

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26 March 2020

M Piwowar

5

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A Broijl

6

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M van Duin

7

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P Sonneveld

8

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M J Kersten

10

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M Spaargaren

11

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S T Pals

12

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26 March 2020

language of work or name

English

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publication date

24 October 2016

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26 March 2020

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26 March 2020

volume

36

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26 March 2020

page(s)

2105-2115

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26 March 2020

issue

15

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https://scigraph.springernature.com/pub.10.1038/onc.2016.368

26 March 2020

exact match

0 references

cites work

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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

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Identification of the familial cylindromatosis tumour-suppressor gene

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The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

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Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

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Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

21 January 2018

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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

21 January 2018

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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

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CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.368

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.368

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

21 January 2018

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Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability.

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CYLD: a deubiquitination enzyme with multiple roles in cancer.

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STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer

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Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

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The molecular classification of multiple myeloma

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Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib

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Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

21 January 2018

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

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The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway

21 January 2018

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Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression

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Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma

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Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma

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Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma

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Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

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Role of members of the Wnt gene family in human hematopoiesis

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27775078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2016.368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27775078%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference