RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. (Q49048892)

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16 February 2020

title

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis (English)

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Peter Vandenabeele

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author name string

Nozomi Takahashi

1

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Lars Vereecke

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Linde Duprez

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Scott B Berger

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Tatyana Divert

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Amanda Gonçalves

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Mozes Sze

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Barbara Gilbert

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Stephanie Kourula

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Vera Goossens

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Sylvie Lefebvre

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Claudia Günther

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Christoph Becker

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John Bertin

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Peter J Gough

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Wim Declercq

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Geert van Loo

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language of work or name

English

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publication date

1 September 2014

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volume

513

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page(s)

95-99

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issue

7516

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https://scigraph.springernature.com/pub.10.1038/nature13706

16 February 2020

exact match

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cites work

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

1 reference

12 December 2020

Epithelial NEMO links innate immunity to chronic intestinal inflammation

1 reference

12 December 2020

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

1 reference

12 December 2020

High resolution colonoscopy in live mice

1 reference

12 December 2020

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

1 reference

12 December 2020

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

1 reference

12 December 2020

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

1 reference

12 December 2020

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

1 reference

12 December 2020

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

1 reference

12 December 2020

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

1 reference

12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

1 reference

12 December 2020

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

1 reference

12 December 2020

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

1 reference

12 December 2020

Bypass of lethality with mosaic mice generated by Cre– loxP -mediated recombination

1 reference

12 December 2020

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

1 reference

12 December 2020

Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains

1 reference

12 December 2020

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

1 reference

12 December 2020

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

12 December 2020

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

1 reference

12 December 2020

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

1 reference

12 December 2020

TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium

1 reference

12 December 2020

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

1 reference

12 December 2020

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

1 reference

12 December 2020

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

1 reference

12 December 2020

Site- and time-specific gene targeting in the mouse

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

1 reference

12 December 2020

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

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12 December 2020

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

1 reference

12 December 2020

Primary mouse small intestinal epithelial cell cultures

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12 December 2020

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

1 reference

12 December 2020

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

1 reference

12 December 2020

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

1 reference

12 December 2020

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

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12 December 2020

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

1 reference

12 December 2020

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

1 reference

12 December 2020

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

1 reference

12 December 2020

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

1 reference

12 December 2020

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1 reference

12 December 2020

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

1 reference

12 December 2020

RIP kinases at the crossroads of cell death and survival

1 reference

12 December 2020

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE13706

1 reference

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16 February 2020

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