Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein. (Q50042580)

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scientific article published on 16 January 2018

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English	Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.	scientific article published on 16 January 2018

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein (English)

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9 April 2020

phosphorylation

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invasive ductal carcinoma

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pancreatic ductal adenocarcinoma

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pancreatic ductal carcinoma

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based on heuristic

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1

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9 April 2020

4

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9 April 2020

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9 April 2020

author name string

Yi-Chieh Yang

2

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9 April 2020

Hsiu-Po Wang

3

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9 April 2020

Chia-Tung Shun

5

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9 April 2020

Hsin-Yi Huang

6

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9 April 2020

Kuo-Tai Hua

8

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9 April 2020

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16 January 2018

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9 April 2020

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9 April 2020

37

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9 April 2020

13

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9 April 2020

1730-1742

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9 April 2020

https://scigraph.springernature.com/pub.10.1038/s41388-017-0086-y

0 references

Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PAK signalling during the development and progression of cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Comparison of plasma Tu-M2-PK and CA19-9 in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The HSP90 chaperone machinery.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Lack of Evidence for PKM2 Protein Kinase Activity

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Structure, biochemistry, and biology of PAK kinases

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Tumor M2-Pyruvate Kinase as Tumor Marker in Exocrine Pancreatic Cancer A Meta-Analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

21 January 2018

Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Heat shock proteins are differentially expressed in human gastrointestinal cancers.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-017-0086-Y

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multifaceted regulation and functions of PKM2 in tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29335522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/S41388-017-0086-Y

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29335522%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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