SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells (Q24338861)

PKM2 pyruvate kinase complex

Gene Ontology ID

GO:1990360

1 reference

Gene Ontology ID

GO:1990361

pyruvate kinase complex

1 reference

Gene Ontology ID

GO:1902912

protein kinase complex

1 reference

1 reference

ChEBI release 2020-05-28

1 reference

ChEBI release 2020-05-28

Kirstie E Keller

1

Kirstie E

Keller

1 reference

6 November 2023

Zainab M Doctor

series ordinal

2

author given names

Zainab M

author last names

Doctor

1 reference

6 November 2023

Zachary W Dwyer

series ordinal

3

author given names

Zachary W

author last names

Dwyer

1 reference

6 November 2023

Young-Sam Lee

series ordinal

4

author given names

Young-Sam

author last names

Lee

1 reference

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

6 November 2023

language of work or name

English

0 references

publication date

6 March 2014

0 references

published in

Molecular Cell

0 references

volume

53

0 references

issue

5

0 references

page(s)

700-9

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Human pyruvate kinase M2: a multifunctional protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Understanding the Warburg effect: the metabolic requirements of cell proliferation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Hallmarks of Cancer: The Next Generation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Mammalian MAP kinase signalling cascades

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Cell cycle regulation by the Cdc25 phosphatase family

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Otto Warburg's contributions to current concepts of cancer metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Emerging roles of PKM2 in cell metabolism and cancer progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

ERK1/2 MAP kinases: structure, function, and regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Positive feedback in cellular control systems.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis"

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Checking on DNA damage in S phase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Pyruvate kinase type M2: a crossroad in the tumor metabolome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Extracellular signals and reversible protein phosphorylation: what to Mek of it all.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Receptors for epidermal growth factor and other polypeptide mitogens

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Ordered phosphorylation of p42mapk by MAP kinase kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Exploiting tumor metabolism: challenges for clinical translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4000728

Phosphoenolpyruvate-dependent protein kinase activity in rat skeletal muscle

30 May 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of phosphoenolpyruvate as a phosphoryl group donor for phosphoproteins in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.02.015

1 reference

release_nl6c3e57obf6rk3ivlrzoh6at4

Fatcat ID

0 references

1 reference

1 reference

1 reference