T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? (Q50778923)

19 March 2018

review article

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title

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? (English)

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19 March 2018

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2

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19 March 2018

author name string

Daniel E Speiser

1

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19 March 2018

Susanne G Oberle

3

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19 March 2018

Christian Münz

4

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19 March 2018

Pedro Romero

5

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19 March 2018

Dietmar Zehn

6

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19 March 2018

publication date

26 September 2014

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19 March 2018

Nature Reviews Immunology

published in

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19 March 2018

volume

14

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19 March 2018

issue

11

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19 March 2018

page(s)

768-774

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19 March 2018

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

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Diversity in T cell memory: an embarrassment of riches

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Functional signatures of protective antiviral T-cell immunity in human virus infections.

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Coinhibitory receptors and CD8 T cell exhaustion in chronic infections

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Molecular mechanisms of T cell co-stimulation and co-inhibition

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Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

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Viral immune evasion due to persistence of activated T cells without effector function

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

31 March 2020

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T cells and viral persistence: lessons from diverse infections

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The blockade of immune checkpoints in cancer immunotherapy

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Features of responding T cells in cancer and chronic infection.

31 March 2020

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T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

31 March 2020

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

31 March 2020

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Redefining chronic viral infection

31 March 2020

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Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

31 March 2020

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Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

31 March 2020

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Restoring function in exhausted CD8 T cells during chronic viral infection

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A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

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T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

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The T-cell response to HIV.

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HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication

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Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects

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The biology of recent thymic emigrants

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Evidence for increased T cell turnover and decreased thymic output in HIV infection

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CD8(+)T-cell-mediated control of HIV-1 and SIV infection

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

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Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

31 March 2020

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Immune clearance of highly pathogenic SIV infection

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Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo.

31 March 2020

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Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients

31 March 2020

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Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

31 March 2020

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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

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The immune contexture in human tumours: impact on clinical outcome

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Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion

31 March 2020

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Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication

31 March 2020

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Exhausted cytotoxic control of Epstein-Barr virus in human lupus

31 March 2020

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Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection

31 March 2020

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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients

31 March 2020

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

31 March 2020

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Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

31 March 2020

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

31 March 2020

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Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape

31 March 2020

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Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

31 March 2020

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Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.

31 March 2020

1 reference

Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57

31 March 2020

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Cellular responses to viral infection in humans: lessons from Epstein-Barr virus.

31 March 2020

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γ-Herpesvirus reactivation differentially stimulates epitope-specific CD8 T cell responses

31 March 2020

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

31 March 2020

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Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

31 March 2020

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Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection

31 March 2020

1 reference

Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells

31 March 2020

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T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

31 March 2020

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Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

31 March 2020

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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

31 March 2020

1 reference

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

31 March 2020

1 reference

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

31 March 2020

1 reference

Heterogeneous differentiation patterns of individual CD8+ T cells.

31 March 2020

1 reference

Disparate individual fates compose robust CD8+ T cell immunity

31 March 2020

1 reference

Effector and memory CTL differentiation

31 March 2020

1 reference

Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

31 March 2020

1 reference

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

31 March 2020

1 reference

Natural killer cells act as rheostats modulating antiviral T cells

31 March 2020

1 reference

Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.

31 March 2020

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Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

31 March 2020

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Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.

31 March 2020

1 reference

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.

31 March 2020

1 reference

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.

31 March 2020

1 reference

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

31 March 2020

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

31 March 2020

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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

31 March 2020

1 reference

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

31 March 2020

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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

31 March 2020

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Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity

31 March 2020

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Memory T cell subsets, migration patterns, and tissue residence

31 March 2020

1 reference

The molecular signature of tissue resident memory CD8 T cells isolated from the brain

31 March 2020

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Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

31 March 2020

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

31 March 2020

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

31 March 2020

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Tumor Immunotherapy Directed at PD-1

31 March 2020

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Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

31 March 2020

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Nivolumab plus ipilimumab in advanced melanoma

31 March 2020

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Combination checkpoint blockade--taking melanoma immunotherapy to the next level.

31 March 2020

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Checkpoint blockade in cancer immunotherapy

31 March 2020

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A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection

31 March 2020

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Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

31 March 2020

1 reference

Enhancing SIV-specific immunity in vivo by PD-1 blockade

31 March 2020

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Ipilimumab-induced hepatitis C viral suppression

31 March 2020

1 reference

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25257362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25257362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25257362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3740

1 reference

19 March 2018

PubMed ID

25257362

1 reference

19 March 2018