Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches (Q50937939)

25 March 2018

title

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches (English)

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25 March 2018

1

Ioana Visan

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25 March 2018

Joanne B Tan

2

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Julie S Yuan

3

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James A Harper

4

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Ute Koch

5

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Cynthia J Guidos

6

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language of work or name

English

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publication date

14 May 2006

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25 March 2018

published in

Nature Immunology

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volume

7

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issue

6

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25 March 2018

page(s)

634-643

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Fine-tuning Notch1 activation by endocytosis and glycosylation

cites work

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.

21 January 2018

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Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

21 January 2018

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

21 January 2018

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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

21 January 2018

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

21 January 2018

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Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

21 January 2018

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Notch signaling controls the generation and differentiation of early T lineage progenitors

21 January 2018

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Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition

21 January 2018

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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

21 January 2018

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Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

21 January 2018

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

21 January 2018

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

21 January 2018

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

21 January 2018

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

21 January 2018

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Notch signaling is an important regulator of type 2 immunity.

21 January 2018

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Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

21 January 2018

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The nervous system and innate immunity: the neuropeptide connection

21 January 2018

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

21 January 2018

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

21 January 2018

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Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

21 January 2018

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The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice

21 January 2018

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Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

21 January 2018

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Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice

21 January 2018

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Regulation of thymus size by competition for stromal niches among early T cell progenitors

21 January 2018

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Notch activity influences the alphabeta versus gammadelta T cell lineage decision

21 January 2018

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Notch regulation of lymphocyte development and function.

21 January 2018

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

21 January 2018

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Glycosylation regulates Notch signalling.

21 January 2018

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The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

21 January 2018

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Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

21 January 2018

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Fringe modulates Notch-ligand interactions.

21 January 2018

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The segmentation clock: converting embryonic time into spatial pattern

21 January 2018

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Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock.

21 January 2018

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Transcriptional oscillation of lunatic fringe is essential for somitogenesis

21 January 2018

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The genetic program of hematopoietic stem cells

21 January 2018

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Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation

21 January 2018

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lunatic fringe is an essential mediator of somite segmentation and patterning

21 January 2018

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The purification and characterization of fetal liver hematopoietic stem cells.

21 January 2018

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Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

21 January 2018

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Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

21 January 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

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Drosophila myc regulates organ size by inducing cell competition

21 January 2018

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dMyc transforms cells into super-competitors

21 January 2018

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Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

21 January 2018

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Correlating notch signaling with thymocyte maturation

21 January 2018

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Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.

21 January 2018

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Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions

21 January 2018

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

21 January 2018

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Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

21 January 2018

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Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

21 January 2018

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

21 January 2018

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7 January 2021

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

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7 January 2021

Functional demonstration of intrathymic binding sites and microvascular gates for prothymocytes in irradiated mice

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7 January 2021

Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors

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7 January 2021

B lymphopoiesis in the thymus

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7 January 2021

Identifiers

DOI

10.1038/NI1345

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25 March 2018

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25 March 2018