CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. (Q51011935)

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scientific article published in April 2011

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English	CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease.	scientific article published in April 2011

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CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease (English)

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cognitive dysfunction

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author name string

Gaëlle Naert

1

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Serge Rivest

2

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publication date

1 April 2011

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13

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Journal of Neuroscience

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31

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6208-6220

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describes a project that uses

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/21508244

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/21508244

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An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia

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Intraneuronal Abeta42 accumulation in human brain.

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Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice

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Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia

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Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.

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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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12 December 2020

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Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components

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Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice

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TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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12 December 2020

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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12 December 2020

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Inflammatory factors are elevated in brain microvessels in Alzheimer's disease

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12 December 2020

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Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes

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Alzheimer's disease is a synaptic failure

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Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease

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12 December 2020

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Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microglia

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CD36 mediates the innate host response to beta-amyloid

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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

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A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.

1 reference

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based on heuristic

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Blood monocytes consist of two principal subsets with distinct migratory properties

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Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.

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Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.

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Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain.

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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

1 reference

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12 December 2020

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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12 December 2020

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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

1 reference

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12 December 2020

based on heuristic

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

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https://pubmed.ncbi.nlm.nih.gov/21508244

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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

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The many roles of chemokines and chemokine receptors in inflammation

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https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Transforming growth factor-beta regulation of immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Control of microglial neurotoxicity by the fractalkine receptor

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12 December 2020

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Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

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12 December 2020

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Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells

1 reference

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12 December 2020

based on heuristic

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

1 reference

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12 December 2020

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular amyloid-beta in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection

1 reference

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based on heuristic

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Exploring the full spectrum of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

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Origins and tissue-context-dependent fates of blood monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Binding and uptake of A beta1-42 by primary human astrocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Monocyte chemoattractant protein-1 (MCP-1): an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages and microglia in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines--chemotactic cytokines that mediate inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

based on heuristic

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Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21508244

12 December 2020

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Identifiers

10.1523/JNEUROSCI.0299-11.2011

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21508244%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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