p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. (Q53594164)

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20 December 2019

title

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo (English)

1 reference

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20 December 2019

7

Li-Huei Tsai

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20 December 2019

author name string

Jonathan C Cruz

1

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20 December 2019

Dohoon Kim

2

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20 December 2019

Lily Y Moy

3

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20 December 2019

Matthew M Dobbin

4

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20 December 2019

Xiaoyan Sun

5

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20 December 2019

Roderick T Bronson

6

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language of work or name

English

0 references

publication date

1 October 2006

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20 December 2019

published in

Journal of Neuroscience

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20 December 2019

volume

26

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20 December 2019

issue

41

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20 December 2019

page(s)

10536-10541

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Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

20 December 2019

cites work

1 reference

12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

12 December 2020

Intraneuronal Abeta42 accumulation in human brain.

1 reference

12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

12 December 2020

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

12 December 2020

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

12 December 2020

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

APP processing is regulated by cytoplasmic phosphorylation

1 reference

12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

12 December 2020

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.

1 reference

12 December 2020

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

12 December 2020

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

1 reference

12 December 2020

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

12 December 2020

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

12 December 2020

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

1 reference

12 December 2020

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

12 December 2020

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

12 December 2020

Intraneuronal compartments of the amyloid precursor protein.

1 reference

12 December 2020

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

12 December 2020

10.1523/JNEUROSCI.3133-06.2006

Identifiers

DOI

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20 December 2019

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