Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis. (Q51071422)

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scientific article published on 3 April 2017

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English	Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis.	scientific article published on 3 April 2017

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis. (English)

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

Arun Radhakrishnan

5

1 reference

Europe PubMed Central

PubMed publication ID

28 March 2018

http://europepmc.org/abstract/MED/28377508

Joseph L. Goldstein

3

object named as

Joseph L Goldstein

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

author name string

Yansong Gao

1

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

Yulian Zhou

2

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

Michael S Brown

4

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

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publication date

3 April 2017

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Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

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9

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Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

292

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

21

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

8729-8737

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.

1 reference

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15 July 2018

Dynamic membrane protein topological switching upon changes in phospholipid environment

1 reference

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15 July 2018

Lipids and topological rules governing membrane protein assembly.

1 reference

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15 July 2018

In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein

1 reference

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15 July 2018

Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi

1 reference

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15 July 2018

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

1 reference

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15 July 2018

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

1 reference

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15 July 2018

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

1 reference

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15 July 2018

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

1 reference

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15 July 2018

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448100

15 July 2018

Protein sensors for membrane sterols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448100

15 July 2018

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

1 reference

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15 July 2018

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

1 reference

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15 July 2018

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448100

15 July 2018

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

1 reference

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15 July 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

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15 July 2018

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

1 reference

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15 July 2018

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

1 reference

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14 August 2018

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

1 reference

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14 August 2018

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

1 reference

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14 August 2018

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448100

14 August 2018

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28377508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28377508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M117.783894

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 July 2018

http://europepmc.org/abstract/PMC/5448100

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