GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1. (Q51360193)

4 April 2018

title

GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1. (English)

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6

Akiyoshi Fukamizu

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4 April 2018

author name string

Jun-ichi Sakamaki

1

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Hiroaki Daitoku

2

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Yuta Kaneko

3

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Ayano Hagiwara

4

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Katsuya Ueno

5

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publication date

5 March 2012

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Journal of Receptors and Signal Transduction

published in

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volume

32

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issue

2

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page(s)

96-101

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Novel concepts in insulin regulation of hepatic gluconeogenesis

cites work

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Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

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Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

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The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

21 January 2018

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A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.

21 January 2018

1 reference

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FOXO transcription factors

21 January 2018

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Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

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FOXO transcription factors in the regulatory networks of longevity

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Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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Glycogen synthase kinase 3: more than a namesake

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GSK3 signalling in neural development

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Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action

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Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

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Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

21 January 2018

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Regulation of FoxO transcription factors by acetylation and protein-protein interactions

21 January 2018

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Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1.

21 January 2018

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10.3109/10799893.2012.660531

21 January 2018

Identifiers

DOI

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4 April 2018

PubMed ID

22384829

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4 April 2018