Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits. (Q51382208)

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25 March 2020

title

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits (English)

1 reference

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25 March 2020

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5

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25 March 2020

Ruben Coronel

6

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25 March 2020

Rob C.I. Wüst

3

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25 March 2020

author name string

Antonius Baartscheer

1

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25 March 2020

Cees A Schumacher

2

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25 March 2020

Jan W T Fiolet

4

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25 March 2020

Coert J Zuurbier

7

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25 March 2020

publication date

17 October 2016

1 reference

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25 March 2020

number of pages

6

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inferred from page(s)

published in

Diabetologia

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25 March 2020

volume

60

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25 March 2020

page(s)

568-573

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25 March 2020

issue

3

1 reference

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Creative Commons Attribution 4.0 International

25 March 2020

copyright license

start time

17 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1007/s00125-016-4134-x

0 references

cites work

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of empagliflozin in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Chronic inhibition of the Na+/H+ - exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-4134-X

Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27752710

12 December 2020

inferred from PubMed ID database lookup

Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27752710

12 December 2020

inferred from PubMed ID database lookup

Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocin-induced diabetic rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27752710

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S00125-016-4134-X

1 reference

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25 March 2020

1 reference

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25 March 2020

1 reference