Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. (Q51546346)

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11 February 2020

title

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1 (English)

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11 February 2020

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2

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11 February 2020

Philippe Meyer

13

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11 February 2020

author name string

H Gaude

1

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11 February 2020

A Delay

3

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11 February 2020

A Bres

4

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11 February 2020

K Buchet-Poyau

5

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11 February 2020

C Caillat

6

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11 February 2020

A Vigouroux

7

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11 February 2020

C Rogon

8

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11 February 2020

A Woods

9

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11 February 2020

J-M Vanacker

10

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11 February 2020

J Höhfeld

11

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11 February 2020

C Perret

12

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11 February 2020

M Billaud

14

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C Forcet

15

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language of work or name

English

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publication date

22 August 2011

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11 February 2020

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11 February 2020

volume

31

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11 February 2020

issue

12

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11 February 2020

page(s)

1582-1591

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LKB1-dependent signaling pathways

11 February 2020

cites work

1 reference

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

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Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

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Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

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Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

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Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

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The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

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Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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LKB1; linking cell structure and tumor suppression

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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CHIP: a link between the chaperone and proteasome systems

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