Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. (Q51730758)

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scientific article published on 29 March 2018

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English	Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation.	scientific article published on 29 March 2018

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21 March 2020

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation (English)

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21 March 2020

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21 March 2020

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Gao-Yuan Liu

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21 March 2020

Rencheng Wang

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21 March 2020

Sung Ho Moon

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21 March 2020

Richard W Gross

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21 March 2020

Gary J Patti

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21 March 2020

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29 March 2018

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21 March 2020

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21 March 2020

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21 March 2020

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21 March 2020

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21 March 2020

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29 March 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

3 July 2018

Inaccurate quantitation of palmitate in metabolomics and isotope tracer studies due to plastics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

3 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

3 July 2018

Structure of mammalian respiratory complex I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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1 reference

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3 July 2018

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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1 reference

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1 reference

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3 July 2018

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3 July 2018

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3 July 2018

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

3 July 2018

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3 July 2018

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1 reference

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High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

3 July 2018

Mitochondrial lipid trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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1 reference

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Human trifunctional protein alpha links cardiolipin remodeling to beta-oxidation

1 reference

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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892939

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1 reference

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1 reference

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1 reference

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Etomoxir: a new approach to treatment of chronic heart failure

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https://pubmed.ncbi.nlm.nih.gov/29596410

12 December 2020

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10.1371/JOURNAL.PBIO.2003782

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21 March 2020

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21 March 2020

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