TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease (Q42777333)

7 November 2017

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease (English)

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Triggering receptor expressed on myeloid cells 2

7 November 2017

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GOA release 2020-03-11

author

Tyler K Ulland

1

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7 November 2017

12

Susan Gilfillan

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Yingyue Zhou

object named as

Yingyue Zhou

8

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Herbert W. Virgin

14

object named as

Herbert W Virgin

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7 November 2017

18

David M Holtzman

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7 November 2017

15

Emil R Unanue

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7 November 2017

19

Marco Colonna

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7 November 2017

9

Nigel J Cairns

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7 November 2017

17

Maxim N Artyomov

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7 November 2017

Wilbur M Song

2

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7 November 2017

Stanley Ching-Cheng Huang

3

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7 November 2017

Jason D Ulrich

4

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7 November 2017

Alexey Sergushichev

5

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7 November 2017

Wandy L Beatty

6

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7 November 2017

Alexander A Loboda

7

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7 November 2017

Amal Kambal

10

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7 November 2017

Ekaterina Loginicheva

11

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7 November 2017

Marina Cella

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7 November 2017

Yaming Wang

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7 November 2017

language of work or name

English

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publication date

1 August 2017

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7 November 2017

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7 November 2017

170

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7 November 2017

649-663.e13

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7 November 2017

4

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describes a project that uses

7 November 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5573224/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5573224

inferred from PubMed Central ID database lookup

cites work

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

27 August 2018

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

27 August 2018

1 reference

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

27 August 2018

1 reference

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27 August 2018

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

27 August 2018

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Complement and microglia mediate early synapse loss in Alzheimer mouse models.

27 August 2018

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27 August 2018

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Immunometabolism governs dendritic cell and macrophage function

27 August 2018

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Microglia in Alzheimer's disease: the good, the bad and the ugly

27 August 2018

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Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.

27 August 2018

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Myeloid cells in Alzheimer's disease: culprits, victims or innocent bystanders?

27 August 2018

1 reference

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

27 August 2018

1 reference

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The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

27 August 2018

1 reference

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β-amyloid, microglia, and the inflammasome in Alzheimer's disease

27 August 2018

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Modulation of inflammation by autophagy: Consequences for human disease

27 August 2018

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The pathogenic role of the inflammasome in neurodegenerative diseases

27 August 2018

1 reference

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

27 August 2018

1 reference

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Innate immunity in Alzheimer's disease

27 August 2018

1 reference

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C-type lectins in immunity: recent developments

27 August 2018

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Metabolic control of autophagy

27 August 2018

1 reference

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Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

27 August 2018

1 reference

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Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

27 August 2018

1 reference

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Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

27 August 2018

1 reference

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

27 August 2018

1 reference

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Microglial priming in neurodegenerative disease

27 August 2018

1 reference

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Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease

27 August 2018

1 reference

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

27 August 2018

1 reference

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The genetics of Alzheimer disease

27 August 2018

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Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency

27 August 2018

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mTOR signaling in growth control and disease

27 August 2018

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Alzheimer mechanisms and therapeutic strategies

27 August 2018

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Alzheimer's disease: the challenge of the second century

27 August 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

27 August 2018

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

27 August 2018

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Autophagy and the integrated stress response

27 August 2018

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Role of PI3K in the generation and survival of B cells

27 August 2018

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5573224

TREM and TREM-like receptors in inflammation and disease

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5573224

Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5573224

Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis

27 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5573224

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

27 August 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

27 August 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

27 August 2018

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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

27 August 2018

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Creatine and the creatine transporter: a review

27 August 2018

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Creatine and creatinine metabolism

27 August 2018

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27 August 2018

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Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism.

30 September 2018

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Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

27 August 2018

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Formation of a supplemental long time-constant reservoir of high energy phosphate by brain in vivo and in vitro and its reversible depletion by potassium depolarization

27 August 2018

1 reference

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Creatine: Biosynthesis, Regulation, and Function

27 August 2018

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Specificity of creatine kinase for guanidino substrates. Kinetic and proton nuclear magnetic relaxation rate studies

27 August 2018

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12 December 2020

Genetics of Alzheimer's disease

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12 December 2020

Cutting Edge: TREM-2 Attenuates Macrophage Activation

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12 December 2020

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

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12 December 2020

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Identifiers

DOI

1 reference

release_2vphmn56pfgurgof24f7yzgjyu

7 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2vphmn56pfgurgof24f7yzgjyu

24 November 2022

mapped directly with Wikidata item

0 references

1 reference