Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. (Q51905484)

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scientific article published on 20 September 2007

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English	Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.	scientific article published on 20 September 2007

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scholarly article

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. (English)

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

author name string

Matt T Bianchi

1

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Emmanuel J Botzolakis

2

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Kevin F Haas

3

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Janet L Fisher

4

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Robert L Macdonald

5

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

language of work or name

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publication date

20 September 2007

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Journal of Physiology

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

584

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Pt 3

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

769-787

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

Desensitization and binding properties determine distinct alpha1beta2gamma2 and alpha3beta2gamma2 GABA(A) receptor-channel kinetic behavior.

1 reference

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Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA

1 reference

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Effect of extracellular pH on recombinant alpha1beta2gamma2 and alpha1beta2 GABAA receptors.

1 reference

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25 August 2018

The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics

1 reference

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Multiple actions of propofol on alphabetagamma and alphabetadelta GABAA receptors

1 reference

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Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents

1 reference

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Use of the covariance matrix in directly fitting kinetic parameters: application to GABAA receptors.

1 reference

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Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists

1 reference

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Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents.

1 reference

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Mechanisms of anabolic androgenic steroid modulation of alpha(1)beta(3)gamma(2L) GABA(A) receptors.

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Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit

1 reference

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Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function

1 reference

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Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.

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Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.

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Functional characterization of the new human GABA(A) receptor mutation beta3(R192H).

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The dissociation of acetylcholine from open nicotinic receptor channels

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Agonist Trapping by GABAA Receptor Channels.

1 reference

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Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states

1 reference

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Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.

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Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.

1 reference

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Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants

1 reference

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Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding.

1 reference

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The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2276985

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Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine

1 reference

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Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation

1 reference

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Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

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Defining affinity with the GABAA receptor.

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Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons.

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The impact of receptor desensitization on fast synaptic transmission

1 reference

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Distinct deactivation and desensitization kinetics of recombinant GABAA receptors

1 reference

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Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.

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Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

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Multiphasic desensitization of the GABAA receptor in outside-out patches

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Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

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The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

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1 reference

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Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

1 reference

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Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

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GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17884921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the desensitization produced by acetylcholine at the motor end-plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17884921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow desensitization regulates the availability of synaptic GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17884921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17884921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17884921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1113/JPHYSIOL.2007.142364

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

0 references

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/17884921

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