Comprehensive Characterization of Cancer Driver Genes and Mutations. (Q52602398)

4 May 2018

title

Comprehensive Characterization of Cancer Driver Genes and Mutations. (English)

1 reference

4 May 2018

Eduard Porta-Pardo

3

0 references

Abel Gonzalez-Perez

Abel Gonzalez-Perez

28

0 references

Núria López-Bigas

Nuria Lopez-Bigas

39

0 references

Antonio Colaprico

Antonio Colaprico

Cancer Genome Atlas Research Network

7

0 references

36

Cancer Genome Atlas Research Network

1 reference

4 May 2018

Isidro Cortés-Ciriano

Isidro Cortés-Ciriano

22

0 references

Alexander J. Lazar

Alexander J Lazar

44

0 references

Gad Getz

42

Gad Getz

1 reference

4 May 2018

0 references

Collin Tokheim

2

0 references

Matthew Bailey

Matthew H Bailey

1

0 references

Jianjiong Gao

Jianjiong Gao

15

0 references

Joshua M Stuart

Josh Stuart

40

0 references

Gordon B. Mills

Gordon B Mills

45

0 references

Ken Chen

Ken Chen

43

0 references

Adam Godzik

Adam Godzik

38

0 references

Loris Mularoni

19

Loris Mularoni

1 reference

4 May 2018

David Tamborero

27

David Tamborero

1 reference

4 May 2018

Rachel Karchin

46

Rachel Karchin

1 reference

4 May 2018

author name string

Sohini Sengupta

4

1 reference

4 May 2018

Denis Bertrand

5

1 reference

4 May 2018

Amila Weerasinghe

6

1 reference

4 May 2018

Michael C Wendl

8

1 reference

4 May 2018

Jaegil Kim

9

1 reference

4 May 2018

Brendan Reardon

10

1 reference

4 May 2018

Patrick Kwok-Shing Ng

11

1 reference

4 May 2018

Kang Jin Jeong

12

1 reference

4 May 2018

Song Cao

13

1 reference

4 May 2018

Zixing Wang

14

1 reference

4 May 2018

Qingsong Gao

16

1 reference

4 May 2018

Fang Wang

17

1 reference

4 May 2018

Eric Minwei Liu

18

1 reference

4 May 2018

Carlota Rubio-Perez

20

1 reference

4 May 2018

Niranjan Nagarajan

21

1 reference

4 May 2018

Daniel Cui Zhou

23

1 reference

4 May 2018

Wen-Wei Liang

24

1 reference

4 May 2018

Julian M Hess

25

1 reference

4 May 2018

Venkata D Yellapantula

26

1 reference

4 May 2018

Chayaporn Suphavilai

29

1 reference

4 May 2018

Jia Yu Ko

30

1 reference

4 May 2018

Ekta Khurana

31

1 reference

4 May 2018

Peter J Park

32

1 reference

4 May 2018

Eliezer M Van Allen

33

1 reference

4 May 2018

Han Liang

34

1 reference

4 May 2018

MC3 Working Group

35

1 reference

4 May 2018

Michael S Lawrence

37

1 reference

4 May 2018

David Wheeler

41

1 reference

4 May 2018

Li Ding

47

1 reference

4 May 2018

language of work or name

English

0 references

publication date

1 April 2018

1 reference

4 May 2018

published in

Cell

1 reference

4 May 2018

volume

173

1 reference

4 May 2018

issue

2

1 reference

4 May 2018

page(s)

371-385.e18

1 reference

4 May 2018

Systematic Functional Annotation of Somatic Mutations in Cancer.

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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

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Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

25 August 2018

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Analysis of protein-coding genetic variation in 60,706 humans

25 August 2018

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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

25 August 2018

1 reference

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OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations

25 August 2018

1 reference

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Protein-structure-guided discovery of functional mutations across 19 cancer types

25 August 2018

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Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure

25 August 2018

1 reference

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Landscape of somatic mutations in 560 breast cancer whole-genome sequences

25 August 2018

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A spectral approach integrating functional genomic annotations for coding and noncoding variants

25 August 2018

1 reference

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The Pfam protein families database: towards a more sustainable future

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Assessing the Pathogenicity of Insertion and Deletion Variants with the Variant Effect Scoring Tool (VEST-Indel).

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Next-generation sequencing to guide cancer therapy

25 August 2018

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Pathway and network analysis of cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Hypermutation in human cancer genomes: footprints and mechanisms

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

e-Driver: a novel method to identify protein regions driving cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Expanding the computational toolbox for mining cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

A general framework for estimating the relative pathogenicity of human genetic variants

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Discovery and saturation analysis of cancer genes across 21 tumour types

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

The landscape of microsatellite instability in colorectal and endometrial cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

CanDrA: cancer-specific driver missense mutation annotation with optimized features

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Mutational landscape and significance across 12 major cancer types

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Comprehensive identification of mutational cancer driver genes across 12 tumor types

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Pan-cancer patterns of somatic copy number alteration

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Emerging patterns of somatic mutations in cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Signatures of mutational processes in human cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Computational approaches to identify functional genetic variants in cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Identifying Mendelian disease genes with the variant effect scoring tool

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

MuPIT interactive: webserver for mapping variant positions to annotated, interactive 3D structures

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Mutational heterogeneity in cancer and the search for new cancer-associated genes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

25 August 2018

Cancer genome landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

CRAVAT: cancer-related analysis of variants toolkit

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Predicting functional effect of human missense mutations using PolyPhen-2.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

MuSiC: identifying mutational significance in cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

The landscape of cancer genes and mutational processes in breast cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

25 August 2018

1 reference

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DNA methylation screening identifies driver epigenetic events of cancer cell survival

25 August 2018

1 reference

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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Predicting the functional impact of protein mutations: application to cancer genomics

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

CHASM and SNVBox: toolkit for detecting biologically important single nucleotide mutations in cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

ModBase, a database of annotated comparative protein structure models, and associated resources

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

A human functional protein interaction network and its application to cancer data analysis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Circos: an information aesthetic for comparative genomics

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Prediction of cancer driver mutations in protein kinases

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Patterns of somatic mutation in human cancer genomes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Cancer genes and the pathways they control

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

A census of human cancer genes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Accounting for human polymorphisms predicted to affect protein function

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6029450

Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer

25 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29625053

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

OncoKB: A Precision Oncology Knowledge Base

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29625053

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2018.02.060

1 reference

4 May 2018

PMC publication ID

6029450

0 references

1 reference

4 May 2018