Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. (Q52617872)

4 May 2018

title

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. (English)

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4 May 2018

author name string

Xiao-Ming Meng

1

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4 May 2018

Xiao Ru Huang

2

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4 May 2018

Jun Xiao

3

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4 May 2018

Arthur C K Chung

4

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4 May 2018

Wei Qin

5

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4 May 2018

Hai-yong Chen

6

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4 May 2018

Hui Yao Lan

7

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4 May 2018

language of work or name

English

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publication date

2 November 2011

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4 May 2018

published in

Kidney International

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4 May 2018

volume

81

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4 May 2018

issue

3

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4 May 2018

page(s)

266-279

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4 May 2018

https://scigraph.springernature.com/pub.10.1038/ki.2011.327

exact match

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cites work

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Renal fibrosis: new insights into the pathogenesis and therapeutics

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Transforming growth factor-beta and Smad signalling in kidney diseases.

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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7 January 2021

Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

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Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.

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7 January 2021

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

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7 January 2021

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

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7 January 2021

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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7 January 2021

Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure

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7 January 2021

Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors.

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7 January 2021

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

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7 January 2021

Regulation of Smad7 promoter by direct association with Smad3 and Smad4.

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7 January 2021

Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta

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7 January 2021

Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney.

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7 January 2021

Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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7 January 2021

TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines

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7 January 2021

Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner

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7 January 2021

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

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Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

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Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants.

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7 January 2021

TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression

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7 January 2021

Generation of Smad4/Dpc4 conditional knockout mice

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7 January 2021

Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract.

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https://api.crossref.org/works/10.1038%2FKI.2011.327

7 January 2021

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

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https://api.crossref.org/works/10.1038%2FKI.2011.327

7 January 2021

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.327

7 January 2021

Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice

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https://api.crossref.org/works/10.1038%2FKI.2011.327

7 January 2021

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

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7 January 2021

Latent TGF-beta1 protects against crescentic glomerulonephritis

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7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.327

7 January 2021

Identifiers

DOI

10.1038/KI.2011.327

1 reference

4 May 2018

PubMed ID

22048127

1 reference

4 May 2018