Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice. (Q53357495)

13 May 2018

title

Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice. (English)

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13 May 2018

author name string

S Yarkoni

1

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13 May 2018

A Kaminitz

2

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13 May 2018

Y Sagiv

3

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13 May 2018

N Askenasy

4

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13 May 2018

publication date

28 November 2009

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13 May 2018

published in

Diabetologia

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13 May 2018

volume

53

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13 May 2018

issue

2

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13 May 2018

page(s)

356-368

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13 May 2018

IL-2, regulatory T cells, and tolerance

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-009-1604-4

A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.

21 January 2018

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Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

21 January 2018

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Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells

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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

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Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice

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CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

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Mechanisms of T regulatory cell function

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Therapeutic potency of IL2-caspase 3 targeted treatment in a murine experimental model of inflammatory bowel disease

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Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells

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Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation

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Immunostimulation circumvents diabetes in NOD/Lt mice

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Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

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12 December 2020

In vivo blockade of the Fas-Fas ligand pathway inhibits cyclophosphamide-induced diabetes in NOD mice

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12 December 2020

Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy

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12 December 2020

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

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The dichotomous role of IL-2: tolerance versus immunity.

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CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity

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Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo

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Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

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Protection from type 1 diabetes by invariant NK T cells requires the activity of CD4+CD25+ regulatory T cells

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A fusion protein composed of IL-2 and caspase-3 ameliorates the outcome of experimental inflammatory colitis

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12 December 2020

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

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12 December 2020

Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice

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12 December 2020

Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells

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12 December 2020

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice

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12 December 2020

A defect in central tolerance in NOD mice

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12 December 2020

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

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12 December 2020

IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.

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VIP and tolerance induction in autoimmunity

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

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Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

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Early clinical studies of IL-2 fusion toxin in patients with severe rheumatoid arthritis and recent onset insulin-dependent diabetes mellitus.

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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Involvement of IL-2 in homeostasis of regulatory T cells: the IL-2 cycle

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CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

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12 December 2020

G-CSF treatment prevents cyclophosphamide acceleration of autoimmune diabetes in the NOD mouse

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12 December 2020

A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model

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12 December 2020

Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression

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12 December 2020

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

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12 December 2020

Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells.

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12 December 2020

CD3-specific antibodies: a portal to the treatment of autoimmunity

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12 December 2020

Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

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12 December 2020

The control of CD4+CD25+Foxp3+ regulatory T cell survival

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12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

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12 December 2020

Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice

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12 December 2020

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

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12 December 2020

Tolerance, not immunity, crucially depends on IL-2.

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12 December 2020

The NOD mouse: a model of immune dysregulation

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12 December 2020

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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12 December 2020

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

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12 December 2020

Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes.

1 reference

12 December 2020

Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells

1 reference

12 December 2020

Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis

1 reference

12 December 2020

10.1007/S00125-009-1604-4

Identifiers

DOI

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13 May 2018

release_lrksvppiejdvfecqj5rlyubjay

Fatcat ID

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Fatcat

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24 November 2022

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13 May 2018