Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. (Q53381705)

13 May 2018

title

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. (English)

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13 May 2018

author name string

Christopher G Evans

series ordinal

1

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13 May 2018

Susanne Wisén

series ordinal

2

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13 May 2018

Jason E Gestwicki

series ordinal

3

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13 May 2018

language of work or name

English

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publication date

14 September 2006

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13 May 2018

Journal of Biological Chemistry

published in

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13 May 2018

volume

281

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13 May 2018

issue

44

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13 May 2018

page(s)

33182-33191

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13 May 2018

Folding proteins in fatal ways

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Amyloid diseases: abnormal protein aggregation in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Progress and problems in the biology, diagnostics, and therapeutics of prion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Peptide inhibitors of beta amyloid aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Human beta-secretase (BACE) and BACE inhibitors: progress report

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Inhibitors and modulators of beta- and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Heat shock response modulators as therapeutic tools for diseases of protein conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Substrate transfer from the chaperone Hsp70 to Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Molecular chaperones and protein quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Structure and in vivo function of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Structural insights into substrate binding by the molecular chaperone DnaK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Roles of molecular chaperones in protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Interaction of intracellular beta amyloid peptide with chaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp20, a novel alpha-crystallin, prevents Abeta fibril formation and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Building dihydropyrimidine libraries via microwave-assisted Biginelli multicomponent reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The Hsp70 and Hsp60 chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Screening for pharmacologic inhibitors of amyloid fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Molecular chaperones in cellular protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Direct measurement of actin polymerization rate constants by electron microscopy of actin filaments nucleated by isolated microvillus cores

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Population-based case-control study of cognitive function in essential tremor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Familial Alzheimer's disease cells abnormally accumulate beta-amyloid-harbouring peptides preferentially in cytosol but not in extracellular fluid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606192200

21 January 2018

Identifiers

DOI

10.1074/JBC.M606192200

1 reference

13 May 2018

1 reference

13 May 2018