Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. (Q53393586)

13 May 2018

title

Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. (English)

1 reference

13 May 2018

0 references

Lei Yan

1

1 reference

13 May 2018

Jiaqi Liang

2

1 reference

13 May 2018

Chengbo Yao

3

1 reference

13 May 2018

Peiyao Wu

4

1 reference

13 May 2018

Xianfeng Zeng

5

1 reference

13 May 2018

Kui Cheng

6

1 reference

13 May 2018

Hang Yin

7

1 reference

13 May 2018

publication date

4 December 2015

1 reference

13 May 2018

published in

ChemMedChem

1 reference

13 May 2018

volume

11

1 reference

13 May 2018

issue

8

1 reference

13 May 2018

page(s)

822-826

1 reference

13 May 2018

Pattern recognition receptors and inflammation

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

The evolution of vertebrate Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Targeting Toll-like receptors with small molecule agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

The Yin and Yang of Toll-like receptors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Toll-like receptor 5 in obesity: the role of gut microbiota and adipose tissue inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Role of TLR5 and flagella in bacillus intraocular infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Functional TLR5 genetic variants affect human colorectal cancer survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Angiogenesis in rheumatoid arthritis is fostered directly by toll-like receptor 5 ligation and indirectly through interleukin-17 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Structural biology and drug discovery of difficult targets: the limits of ligandability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Fine-tuning multiprotein complexes using small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

A peptide antagonist of the TLR4-MD2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Discovery of small-molecule inhibitors of the TLR1/TLR2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Structural study of binding of flagellin by Toll-like receptor 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

Structural basis of TLR5-flagellin recognition and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500471

21 January 2018

Identifiers

DOI

10.1002/CMDC.201500471

1 reference

13 May 2018

1 reference

13 May 2018