α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. (Q53620505)

30 June 2019

title

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. (English)

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30 June 2019

Richard O Hynes

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author name string

Christopher J Turner

1

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30 June 2019

Kwabena Badu-Nkansah

2

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30 June 2019

Denise Crowley

3

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30 June 2019

Arjan van der Flier

4

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30 June 2019

language of work or name

English

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publication date

1 February 2015

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30 June 2019

number of pages

12

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inferred from page(s)

published in

Development

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30 June 2019

volume

142

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30 June 2019

issue

4

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30 June 2019

page(s)

797-808

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30 June 2019

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

cites work

1 reference

12 December 2020

Fate of the mammalian cardiac neural crest

1 reference

12 December 2020

The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease

1 reference

12 December 2020

Inflammatory cytokines stimulate vascular smooth muscle cells locomotion and growth by enhancing alpha5beta1 integrin expression and function.

1 reference

12 December 2020

Regional differences in integrin expression: role of alpha(5)beta(1) in regulating smooth muscle cell functions

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12 December 2020

Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins

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12 December 2020

Adhesion receptors of vascular smooth muscle cells and their functions.

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12 December 2020

The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling

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12 December 2020

The integrin alphaVbeta6 binds and activates latent TGFbeta3.

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12 December 2020

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

1 reference

12 December 2020

Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

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12 December 2020

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

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12 December 2020

Isolation of vascular smooth muscle cells from a single murine aorta

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12 December 2020

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

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12 December 2020

Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin

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12 December 2020

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects

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12 December 2020

Differential expression of integrin alpha5beta1 in human abdominal aortic aneurysm and healthy aortic tissues and its significance in pathogenesis

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12 December 2020

Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development

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12 December 2020

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

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12 December 2020

Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart

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12 December 2020

Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation

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12 December 2020

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12 December 2020

Role for the alpha7beta1 integrin in vascular development and integrity

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12 December 2020

Non-Smad TGF-beta signals

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12 December 2020

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly

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12 December 2020

Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos

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12 December 2020

Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects

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12 December 2020

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

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12 December 2020

Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

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12 December 2020

Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation.

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12 December 2020

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment

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12 December 2020

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly

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12 December 2020

Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.

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12 December 2020

Cell-matrix adhesion in vascular development

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12 December 2020

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

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12 December 2020

A global double-fluorescent Cre reporter mouse

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12 December 2020

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins

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12 December 2020

Extracellular control of TGFbeta signalling in vascular development and disease

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12 December 2020

Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.

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12 December 2020

Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability

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12 December 2020

The developmental genetics of congenital heart disease.

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12 December 2020

The flow field along the entire length of mouse aorta and primary branches

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12 December 2020

Developmental origin of smooth muscle cells in the descending aorta in mice.

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12 December 2020

Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes

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12 December 2020

Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

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12 December 2020

Fibronectins in vascular morphogenesis

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12 December 2020

Aortic arch morphogenesis and flow modeling in the chick embryo.

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12 December 2020

Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5.

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12 December 2020

Vascular extracellular matrix and arterial mechanics

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12 December 2020

Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.

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12 December 2020

Cellular and molecular mechanisms of thoracic aortic aneurysms

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12 December 2020

The extracellular matrix: not just pretty fibrils

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12 December 2020

Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?

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12 December 2020

Sm22α transcription occurs at the early onset of the cardiovascular system and the intron 1 is dispensable for its transcription in smooth muscle cells during mouse development.

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12 December 2020

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development

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12 December 2020

Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest

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12 December 2020

TGF-β signaling in aortic aneurysm: another round of controversy.

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12 December 2020

Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature

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12 December 2020

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

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12 December 2020

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall

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12 December 2020

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin

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12 December 2020

The neural crest in cardiac congenital anomalies

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12 December 2020

Matrix control of transforming growth factor-β function

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12 December 2020

Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension

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12 December 2020

Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway

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12 December 2020

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis

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12 December 2020

The 22q11 deletion: DiGeorge and velocardiofacial syndromes and the role of TBX1.

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12 December 2020

Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells

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12 December 2020

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

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12 December 2020

Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall

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12 December 2020

Plasma fibronectin promotes modulation of arterial smooth-muscle cells from contractile to synthetic phenotype

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12 December 2020

Neural crest cells contribute to normal aorticopulmonary septation

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12 December 2020

Embryonic mesodermal defects in alpha 5 integrin-deficient mice

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12 December 2020

Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin

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12 December 2020

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

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12 December 2020

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium

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12 December 2020

Neural crest and cardiovascular patterning.

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12 December 2020

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

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12 December 2020

Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.

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12 December 2020

Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins

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12 December 2020

Integrin-mediated reduction in vascular smooth muscle [Ca2+]i induced by RGD-containing peptide

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12 December 2020

Potential roles of osteopontin and alphaVbeta3 integrin in the development of coronary artery restenosis after angioplasty

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12 December 2020

Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells.

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12 December 2020

Neural crest cell contribution to the developing circulatory system: implications for vascular morphology?

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12 December 2020

Vitronectin regulates smooth muscle contractility via alphav and beta1 integrin

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12 December 2020

Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1

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12 December 2020

Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins

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12 December 2020

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

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12 December 2020

Generalized lacZ expression with the ROSA26 Cre reporter strain

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12 December 2020

Identifiers

DOI

10.1242/DEV.117572

1 reference

30 June 2019

PMC publication ID

6514387

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30 June 2019

PubMed publication ID

25670798

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30 June 2019