Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase (Q73466868)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

7

William C Hahn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Jean J Zhao

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Ole V Gjoerup

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Yuan Cheng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Wen Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Thomas M Roberts

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

publication date

1 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

483-495

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

4 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Regulatory and signaling properties of the Vav family

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Distinct requirements for Ras oncogenesis in human versus mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Monoclonal antibodies specific for simian virus 40 tumor antigens

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Growth-factor-dependent mitogenesis requires two distinct phases of signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

c-MYC: more than just a matter of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

EPS8 and E3B1 transduce signals from Ras to Rac

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Transformation of normal human cells in the absence of telomerase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Understanding Ras: 'it ain't over 'til it's over'.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Functional and molecular analyses of 10q deletions in human gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

New link in a web of human genes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Control of protein phosphatase 2A by simian virus 40 small-t antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Critical role for SV40 small-t antigen in human cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900088-6

7 January 2021

10.1016/S1535-6108(03)00088-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12781366%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference