Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. (Q54410209)

29 May 2018

http://europepmc.org/abstract/MED/24019118

title

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. (English)

1 reference

29 May 2018

http://europepmc.org/abstract/MED/24019118

author

Camillo Rosano

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Marcello Maggiolini

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Maria Francesca Santolla

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Vincenzo Pezzi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Rosa Sirianni

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Adele Chimento

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ivan Casaburi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Paola Avena

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Arianna De Luca

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Carmela Campana

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Emilia Martire

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

9 September 2013

1 reference

29 May 2018

http://europepmc.org/abstract/MED/24019118

published in

Molecular Nutrition and Food Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

478-489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

cites work

Global cancer statistics

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The multiethnic cohort study: exploring genes, lifestyle and cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Biomarkers for the clinical management of breast cancer: international perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Steroid hormones, receptors, and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

General keynote: the impact of cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Role of oxygen radicals in DNA damage and cancer incidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Olive-oil consumption and health: the possible role of antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Hydroxytyrosol: from laboratory investigations to future clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Targeting estrogen receptor-α reduces adrenocortical cancer (ACC) cell growth in vitro and in vivo: potential therapeutic role of selective estrogen receptor modulators (SERMs) for ACC treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Virtual and biomolecular screening converge on a selective agonist for GPR30.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The unfolding stories of GPR30, a new membrane-bound estrogen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

A death-promoting role for extracellular signal-regulated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Apoptosis: unmasking the executioner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Deadly conversations: nuclear-mitochondrial cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Heregulin-β1-induced GPR30 upregulation promotes the migration and invasion potential of SkBr3 breast cancer cells via ErbB2/ErbB3-MAPK/ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

G protein-coupled receptors: novel targets for drug discovery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Cross-talk between GPER and growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Cyclin D1 in breast cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Transient and sustained ERK phosphorylation and nuclear translocation in growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: a review of in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Olive oil, an essential component of the Mediterranean diet, and breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Mediterranean dietary pattern and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300323

21 January 2018

Identifiers

DOI

10.1002/MNFR.201300323

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24019118%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference