Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. (Q54515107)

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29 January 2020

title

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation (English)

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29 January 2020

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3

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29 January 2020

Motoshi Ichikawa

5

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29 January 2020

Masahiro Nakagawa

4

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author name string

Mayumi Yoshimi

1

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29 January 2020

Susumu Goyama

2

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29 January 2020

Yoichi Imai

6

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29 January 2020

Keiki Kumano

7

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29 January 2020

Takashi Asai

8

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29 January 2020

James C Mulloy

9

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29 January 2020

Andrew S Kraft

10

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29 January 2020

Tsuyoshi Takahashi

11

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29 January 2020

Naoki Shirafuji

12

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29 January 2020

Mineo Kurokawa

13

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language of work or name

English

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publication date

1 April 2012

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European Journal of Immunology

29 January 2020

published in

1 reference

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volume

42

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issue

4

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page(s)

1044-1050

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

29 January 2020

cites work

1 reference

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AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

21 January 2018

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The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

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The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

21 January 2018

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Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation

21 January 2018

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Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

21 January 2018

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AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex

21 January 2018

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Regulation of RUNX1/AML1 during the G2/M transition.

21 January 2018

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Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation

21 January 2018

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Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation

21 January 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

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AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

21 January 2018

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Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

21 January 2018

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Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene

21 January 2018

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Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

21 January 2018

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Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development

21 January 2018

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