AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis (Q36574180)

15 August 2017

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title

AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis (English)

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15 August 2017

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Mineo Kurokawa

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15 August 2017

1 August 2006

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International Journal of Hematology

15 August 2017

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15 August 2017

84

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15 August 2017

2

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15 August 2017

136-142

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https://scigraph.springernature.com/pub.10.1532/ijh97.06070

15 August 2017

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cites work

VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic development

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12 December 2020

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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12 December 2020

In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region

1 reference

12 December 2020

Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development.

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12 December 2020

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

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12 December 2020

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

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12 December 2020

The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

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12 December 2020

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

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12 December 2020

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

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12 December 2020

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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12 December 2020

The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

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12 December 2020

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

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12 December 2020

Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

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12 December 2020

Runx1/AML1 in normal and abnormal hematopoiesis.

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12 December 2020

RUNX1/AML1: a central player in hematopoiesis

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12 December 2020

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

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12 December 2020

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

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12 December 2020

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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12 December 2020

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

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12 December 2020

Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

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12 December 2020

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

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12 December 2020

Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators

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12 December 2020

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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12 December 2020

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

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12 December 2020

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

1 reference

12 December 2020

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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12 December 2020

Runx1/AML1 in leukemia: disrupted association with diverse protein partners

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12 December 2020

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

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12 December 2020

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

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12 December 2020

In vitro development of primitive and definitive erythrocytes from different precursors

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12 December 2020

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

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12 December 2020

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

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12 December 2020

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

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12 December 2020

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

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12 December 2020

Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.

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12 December 2020

Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy

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12 December 2020

Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura.

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12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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12 December 2020

Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development

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12 December 2020

Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis.

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12 December 2020

A role for hematopoietic stem cells in promoting angiogenesis

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12 December 2020

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

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12 December 2020

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

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12 December 2020

Identifiers

DOI

10.1532/IJH97.06070

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PubMed ID

16926135

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

16926135