Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway. (Q54550039)

31 May 2018

title

Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway. (English)

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31 May 2018

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Zheng Zhang

1

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31 May 2018

Mi Wang

2

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31 May 2018

Sheng-Jiang Xue

3

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31 May 2018

Dong-Hong Liu

4

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31 May 2018

Yong-Bo Tang

5

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31 May 2018

publication date

1 February 2012

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31 May 2018

Cardiovascular Drugs and Therapy

published in

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31 May 2018

volume

26

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31 May 2018

issue

1

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31 May 2018

page(s)

31-40

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31 May 2018

Endothelial dysfunction: a strategic target in the treatment of hypertension?

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

21 January 2018

Endothelial dysfunction

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Dysfunction of endothelial nitric oxide synthase and atherosclerosis

21 January 2018

1 reference

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Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats

21 January 2018

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Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension

21 January 2018

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Statin therapy for stroke prevention

21 January 2018

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Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

21 January 2018

1 reference

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Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment

21 January 2018

1 reference

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Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

21 January 2018

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Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel

21 January 2018

1 reference

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Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Genistein Prevents Myocardial Hypertrophy in 2-Kidney 1-Clip Renal Hypertensive Rats by Restoring eNOS Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

21 January 2018

1 reference

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Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension

21 January 2018

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Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways

21 January 2018

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Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10557-011-6351-3

10.1007/S10557-011-6351-3

21 January 2018

Identifiers

DOI

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31 May 2018

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31 May 2018