Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability. (Q54660240)

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12 January 2020

title

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability (English)

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12 January 2020

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3

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12 January 2020

author name string

Qinghua Chen

series ordinal

1

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12 January 2020

Jeffrey Thorpe

series ordinal

2

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12 January 2020

language of work or name

English

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publication date

7 June 2005

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Journal of Biological Chemistry

12 January 2020

published in

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12 January 2020

volume

280

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12 January 2020

issue

34

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12 January 2020

page(s)

30009-30017

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Alpha-synuclein and Parkinson's disease

12 January 2020

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Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

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beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein

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Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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21 January 2018

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Identifiers

DOI

10.1074/JBC.M501308200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15941712%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference