Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials. (Q55103799)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29854275%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials (English)

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29 March 2020

2

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29 March 2020

Jeffrey P. Townsend

series ordinal

4

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29 March 2020

1

Jon F Wilkins

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29 March 2020

author name string

Brian Shuch

series ordinal

3

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29 March 2020

language of work or name

English

0 references

publication date

27 April 2018

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29 March 2020

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29 March 2020

volume

9

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29 March 2020

issue

32

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29 March 2020

page(s)

22243-22253

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Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

29 March 2020

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications

22 June 2018

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COSMIC: exploring the world's knowledge of somatic mutations in human cancer

22 June 2018

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Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution

22 June 2018

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22 June 2018

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Intratumor heterogeneity alters most effective drugs in designed combinations

22 June 2018

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Successes and limitations of targeted therapies in renal cell carcinoma

22 June 2018

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Successes and limitations of targeted cancer therapy in ovarian cancer

22 June 2018

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Successes and limitations of targeted cancer therapy in melanoma

22 June 2018

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Successes and limitations of targeted cancer therapy in lung cancer

22 June 2018

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Successes and limitations of targeted cancer therapy in gastrointestinal stromal tumors

22 June 2018

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Successes and limitations of targeted cancer therapy in colon cancer

22 June 2018

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Successes and limitations of targeted cancer therapy in breast cancer

22 June 2018

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Modeling mutual exclusivity of cancer mutations

22 June 2018

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Molecularly targeted cancer therapy: some lessons from the past decade

22 June 2018

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Addressing genetic tumor heterogeneity through computationally predictive combination therapy

22 June 2018

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Somatic alterations as the basis for resistance to targeted therapies

22 June 2018

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The causes and consequences of genetic heterogeneity in cancer evolution

22 June 2018

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Mutational heterogeneity in cancer and the search for new cancer-associated genes

22 June 2018

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22 June 2018

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Cellular heterogeneity and molecular evolution in cancer

22 June 2018

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The role of BRAF V600 mutation in melanoma

22 June 2018

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22 June 2018

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NRAS mutation status is an independent prognostic factor in metastatic melanoma

22 June 2018

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Crosstalk between the FGFR2 and TP53 genes in breast cancer: data from an association study and epistatic interaction analysis.

22 June 2018

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22 June 2018

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22 June 2018

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Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With Imatinib

22 June 2018

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Hallmarks of Cancer: The Next Generation

22 June 2018

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Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.

22 June 2018

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Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes

22 June 2018

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A comprehensive catalogue of somatic mutations from a human cancer genome

22 June 2018

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Genome-wide functional synergy between amplified and mutated genes in human breast cancer

22 June 2018

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Combinatorial patterns of somatic gene mutations in cancer

22 June 2018

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Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.

22 June 2018

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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

22 June 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

22 June 2018

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The retinoblastoma protein is required for Ras-induced oncogenic transformation

22 June 2018

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Towards quantitative biology: integration of biological information to elucidate disease pathways and to guide drug discovery

22 June 2018

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

22 June 2018

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BRCA1 and BRCA2: 1994 and beyond

22 June 2018

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Mutations of the BRAF gene in human cancer

22 June 2018

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Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

22 June 2018

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

22 June 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

22 June 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

22 June 2018

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

22 June 2018

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Heterogeneity and mutation in KRAS and associated oncogenes: evaluating the potential for the evolution of resistance to targeting of KRAS G12C.

22 June 2018

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Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors.

13 August 2018

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Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments.

13 August 2018

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Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non-Small-Cell Lung Cancer.

13 August 2018

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Inferring the paths of somatic evolution in cancer.

13 August 2018

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Tissue, cell and stage specificity of (epi)mutations in cancers

13 August 2018

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Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

30 November 2018

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12 December 2020

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

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12 December 2020

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

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12 December 2020

Genetic Interactions in Cancer Progression and Treatment

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12 December 2020

Molecular analysis for therapy choice: NCI MATCH

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12 December 2020

Basket Trials and the Evolution of Clinical Trial Design in an Era of Genomic Medicine

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12 December 2020

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29854275%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29854275%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference