MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. (Q55319096)

1 July 2018

title

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. (English)

1 reference

1 July 2018

Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

corrigendum / erratum

1 reference

Giorgio Milazzo

2

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Jan Koster

object named as

Jan Koster

7

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Saurabh Agarwal

object named as

Saurabh Agarwal

1

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author name string

Kimal Rajapakshe

3

1 reference

1 July 2018

Ronald Bernardi

4

1 reference

1 July 2018

Zaowen Chen

5

1 reference

1 July 2018

Eveline Barberi

6

1 reference

1 July 2018

Giovanni Perini

8

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1 July 2018

Cristian Coarfa

9

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1 July 2018

Jason M Shohet

10

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1 July 2018

language of work or name

English

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publication date

17 April 2018

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1 July 2018

published in

Oncotarget

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1 July 2018

volume

9

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1 July 2018

issue

29

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1 July 2018

page(s)

20323-20338

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1 July 2018

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

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3 July 2018

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3 July 2018

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The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

3 July 2018

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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

3 July 2018

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Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma

3 July 2018

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3 July 2018

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Reactivation of p53 via MDM2 inhibition

3 July 2018

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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

3 July 2018

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3 July 2018

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3 July 2018

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Transcription factors that interact with p53 and Mdm2

3 July 2018

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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

3 July 2018

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Mutational dynamics between primary and relapse neuroblastomas.

3 July 2018

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Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma.

3 July 2018

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G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation.

3 July 2018

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Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

3 July 2018

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CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

3 July 2018

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3 July 2018

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Constant rate of p53 tetramerization in response to DNA damage controls the p53 response

3 July 2018

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Striking dichotomy in outcome of MYCN-amplified neuroblastoma in the contemporary era.

3 July 2018

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An overview of MYC and its interactome

3 July 2018

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Super-enhancers in the control of cell identity and disease

3 July 2018

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Activation and control of p53 tetramerization in individual living cells

3 July 2018

1 reference

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Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma

3 July 2018

1 reference

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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

3 July 2018

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Surf the post-translational modification network of p53 regulation

3 July 2018

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Mutant p53 cooperates with ETS2 to promote etoposide resistance

3 July 2018

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p53 requires an intact C-terminal domain for DNA binding and transactivation

3 July 2018

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3 July 2018

1 reference

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Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression.

3 July 2018

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3 July 2018

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A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis-survival balance

3 July 2018

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Role of p53 serine 46 in p53 target gene regulation

3 July 2018

1 reference

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Transcriptional regulation by p53.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

The tumor suppressor p53: from structures to drug discovery

3 July 2018

1 reference

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LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

3 July 2018

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The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

p53 is regulated by the lysine demethylase LSD1

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

3 July 2018

Putting p53 in Context

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

The "readers" of unacetylated p53 represent a new class of acidic domain proteins.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

Outcome of children with neuroblastoma after progression or relapse. A retrospective study of the Italian neuroblastoma registry.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain

12 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945521

59-gene prognostic signature sub-stratifies high-risk neuroblastoma patients

30 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/29755654

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.24859

1 reference

1 July 2018

PMC publication ID

5945521

1 reference

1 July 2018

PubMed publication ID

29755654

1 reference

1 July 2018