Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation (Q57423395)

1

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Anita Weinberg

2

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Jonathan Chee

3

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Lina Mariana

4

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Rochelle Ayala

5

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Philip J. O'connell

7

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Thomas Loudovaris

8

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Mark J. Cowley

9

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Thomas W. Kay

10

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Shane T. Grey

11

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Helen E. Thomas

Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?

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publication date

January 2012

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published in

Cell Transplantation

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volume

21

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issue

1

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page(s)

49-60

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cites work

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Autoantibody response to islet transplantation in type 1 diabetes

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Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli

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The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis

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Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats

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Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

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Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

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Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?

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The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice.

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XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes

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Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas.

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

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Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function

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Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

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A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations

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Summaries of Affymetrix GeneChip probe level data

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Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

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Variables in organ donors that affect the recovery of human islets of Langerhans

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Overexpression of vascular endothelial growth factor in vitro using deferoxamine: a new drug to increase islet vascularization during transplantation

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Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection

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Culture medium modulates proinflammatory conditions of human pancreatic islets before transplantation.

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Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

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Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

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Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

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Short-term culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis in transplanted islets and improves the metabolic outcome of the graft

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Caspase-3 inhibitor prevents apoptosis of human islets immediately after isolation and improves islet graft function

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Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation

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Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation

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Brain death and its influence on donor organ quality and outcome after transplantation

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ER stress triggers apoptosis by activating BH3-only protein Bim

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

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Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

21 January 2018

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Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction

21 January 2018

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Beneficial effect of 1,25 dihydroxyvitamin D3 on cytokine-treated human pancreatic islets.

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Automated method for isolation of human pancreatic islets

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Selection of a suitable internal control gene for expression studies in pancreatic islet grafts

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The non-immune RIP-Kb mouse is a useful host for islet transplantation, as the diabetes is spontaneous, mild and predictable

21 January 2018

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21 January 2018

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Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

21 January 2018

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Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

21 January 2018

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Inflammatory blockade improves human pancreatic islet function and viability

21 January 2018

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