Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. (Q33688622)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959756%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax (English)

1 reference

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13 February 2020

1 reference

5

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13 February 2020

Philippe Bouillet

6

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13 February 2020

Andreas Strasser

9

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13 February 2020

author name string

Mark D McKenzie

1

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13 February 2020

Emma Jamieson

2

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13 February 2020

Elisa S Jansen

3

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13 February 2020

Clare L Scott

4

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13 February 2020

Janette Allison

7

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13 February 2020

Thomas W H Kay

8

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13 February 2020

Helen E Thomas

10

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13 February 2020

language of work or name

English

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publication date

3 December 2009

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13 February 2020

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13 February 2020

volume

59

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13 February 2020

issue

3

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13 February 2020

page(s)

644-652

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

13 February 2020

copyright license

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli

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Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

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Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

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ER stress triggers apoptosis by activating BH3-only protein Bim

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 June 2018

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 June 2018

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Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

21 June 2018

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Five stages of evolving beta-cell dysfunction during progression to diabetes

21 June 2018

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

21 June 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 June 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 June 2018

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21 June 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

21 June 2018

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 June 2018

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21 June 2018

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21 June 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

30 October 2018

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Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

30 October 2018

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30 October 2018

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30 October 2018

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Assaying cytochrome C translocation during apoptosis

30 October 2018

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Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

30 October 2018

1 reference

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Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction

30 October 2018

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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

30 October 2018

1 reference

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Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

30 October 2018

1 reference

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19959756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19959756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB09-1151

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959756%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19959756%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference