Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes (Q57503376)

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18 February 2020

title

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes (English)

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18 February 2020

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Marco Bugliani

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18 February 2020

Piero Marchetti

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author name string

Matilde Masini

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18 February 2020

Luisa Martino

4

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18 February 2020

Pellegrino Masiello

5

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Vincenzo De Tata

7

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publication date

25 November 2012

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18 February 2020

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18 February 2020

volume

49 Suppl 1

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issue

S1

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page(s)

S247-52

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https://scigraph.springernature.com/pub.10.1007/s00592-012-0446-6

18 February 2020

exact match

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cites work

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Functional and molecular defects of pancreatic islets in human type 2 diabetes

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Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets

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Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells

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Insulin granule dynamics in pancreatic beta cells

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The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

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The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

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The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited

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The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

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Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

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Novel aspects of the molecular mechanisms controlling insulin secretion

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Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.

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Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

21 January 2018

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Docking is not a prerequisite but a temporal constraint for fusion of secretory granules

21 January 2018

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Rim2alpha determines docking and priming states in insulin granule exocytosis

21 January 2018

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The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

21 January 2018

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10.1007/S00592-012-0446-6

21 January 2018

Identifiers

DOI

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18 February 2020

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