Targeting cerebrovascular Rho-kinase in stroke (Q57559209)

Expert Opinion on Therapeutic Targets

Europe PubMed Central

title

Targeting cerebrovascular Rho-kinase in stroke (English)

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Salvatore Salomone

2

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author name string

Hwa Kyoung Shin

series ordinal

1

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Cenk Ayata

series ordinal

3

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language of work or name

English

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publication date

13 November 2008

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published in

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volume

12

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issue

12

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page(s)

1547-1564

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cites work

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

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Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

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ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo

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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

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Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

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Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

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Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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Rho GTPases and the regulation of endothelial permeability

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NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke

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Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.

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Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

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Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates

21 January 2018

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RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability

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Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

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21 January 2018

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Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.

21 January 2018

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N-cadherin juxtamembrane domain modulates voltage-gated Ca2+ current via RhoA GTPase and Rho-associated kinase.

21 January 2018

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Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA

21 January 2018

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Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.

21 January 2018

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p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling

21 January 2018

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Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.

21 January 2018

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Astrocyte stellation induced by Rho kinase inhibitors in culture

21 January 2018

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ROCK inhibition with Y27632 activates astrocytes and increases their expression of neurite growth-inhibitory chondroitin sulfate proteoglycans.

21 January 2018

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RhoA and ROCK promote migration by limiting membrane protrusions

21 January 2018

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Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction.

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Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

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Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

21 January 2018

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Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets

21 January 2018

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Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats

21 January 2018

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RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats

21 January 2018

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Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle

21 January 2018

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Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension

21 January 2018

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Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.

21 January 2018

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Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo

21 January 2018

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Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension

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Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

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Involvement of Rho-kinase in experimental vascular endothelial dysfunction

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RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction

21 January 2018

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High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kappaB activation in bovine aortic endothelial cells

21 January 2018

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Cholesterol Primes Vascular Smooth Muscle to Induce Ca 2 Sensitization Mediated by a Sphingosylphosphorylcholine–Rho-Kinase Pathway

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Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice

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Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease

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Immunohistochemical analysis of protein expression after middle cerebral artery occlusion in mice

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GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice

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Effect of focal cerebral infarctions on lesional RhoA and RhoB expression.

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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms

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Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

21 January 2018

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Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.

21 January 2018

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Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

21 January 2018

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Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model

21 January 2018

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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

21 January 2018

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The effects of HA1077, a novel protein kinase inhibitor, on reductions of cerebral blood flow and glucose metabolism following acute and/or chronic bilateral carotid artery ligation in Wistar rats.

21 January 2018

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Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.

21 January 2018

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Rho kinases in cardiovascular physiology and pathophysiology

21 January 2018

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ROCKs as therapeutic targets in cardiovascular diseases

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Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.

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21 January 2018

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21 January 2018

Ischaemic brain oedema

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RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate

21 January 2018

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Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina

21 January 2018

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Nitric oxide: a downstream mediator of calcium toxicity in the ischemic cascade

21 January 2018

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A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

21 January 2018

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Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats.

21 January 2018

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Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.

21 January 2018

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Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain

21 January 2018

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Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

21 January 2018

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Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial

21 January 2018

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A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

21 January 2018

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Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia

21 January 2018

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Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats

21 January 2018

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Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil

21 January 2018

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Cardiovascular effects of Y-27632, a selective Rho-associated kinase inhibitor, assessed in the halothane-anesthetized canine model

21 January 2018

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Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function: role of nitric oxide and Rho-kinase

21 January 2018

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Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations.

21 January 2018

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Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension

21 January 2018

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A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.

21 January 2018

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Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

21 January 2018

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Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial

21 January 2018

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Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

21 January 2018

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Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats

21 January 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

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Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

21 January 2018

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1,026 experimental treatments in acute stroke

21 January 2018

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Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3.

21 January 2018

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HA1077, a novel calcium antagonistic antivasospasm drug, increases both cerebral blood flow and glucose metabolism in conscious rats.

21 January 2018

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The effects of HA1077 on the cerebral circulation after subarachnoid haemorrhage in dogs

21 January 2018

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Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability

21 January 2018

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