Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane (Q57976930)

From Wikidata

Jump to navigation Jump to search

scientific article published in Journal of Biological Chemistry

Language	Label	Description	Also known as
English	Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane	scientific article published in Journal of Biological Chemistry

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

multiple drug resistance

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

author name string

D M Clarke

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

language of work or name

0 references

publication date

1 December 2000

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

275

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

50

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

39272-39278

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

The physiological function of drug-transporting P-glycoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Multidrug resistance in oncology: diagnostic and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

The structure of bacteriorhodopsin: an emerging consensus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Structure of bacteriorhodopsin at 1.55 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Mutational analysis of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. Modulation of drug resistance profiles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Localization of the iodomycin binding site in hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007741200

21 January 2018

Identifiers

10.1074/JBC.M007741200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013259%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q57976930&oldid=1910710675"