Excitotoxicity in Huntington disease (Q58041483)

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Cloned glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Blockade of glutamatergic transmission as treatment for dyskinesias and motor fluctuations in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Riluzole for levodopa-induced dyskinesias in advanced Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

1 reference

7 January 2021

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Selective sparing of a class of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

An immunohistochemical investigation of the human neostriatum in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

The quinolinic acid model of Huntington's disease: locomotor abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

The fatal attraction of polyglutamine-containing proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Calpain activation in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Recent advances in understanding the pathogenesis of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

NMDA receptor function in mouse models of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Separating dual effects of zinc at recombinant N-methyl-D-aspartate receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

High-affinity zinc inhibition of NMDA NR1-NR2A receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Subtype-dependence of NMDA receptor channel open probability.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Differential sensitivity of medium- and large-sized striatal neurons to NMDA but not kainate receptor activation in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Mutant huntingtin enhances excitotoxic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Subunit-specific NMDA receptor trafficking to synapses

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Ligand-gated ion channel interactions with cytoskeletal and signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Identification of proteins in the postsynaptic density fraction by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Calcium-induced actin depolymerization reduces NMDA channel activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1566-2772%2803%2900054-9

7 January 2021