Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling (Q58095951)

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scientific article published in Journal of Biological Chemistry

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English	Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling	scientific article published in Journal of Biological Chemistry

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30377251%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30377251%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Nicola C Partridge

5

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1 May 2020

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Florante R Ricarte

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1 May 2020

Carole Le Henaff

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1 May 2020

Victoria G Kolupaeva

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1 May 2020

Thomas J Gardella

4

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1 May 2020

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30 October 2018

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1 May 2020

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14

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Journal of Biological Chemistry

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1 May 2020

293

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1 May 2020

52

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1 May 2020

20200-20213

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1 May 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6311504/fullTextXML

based on heuristic

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Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

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https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B'' (delta) regulatory subunit in vitro and identification of the phosphorylation sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3',5'-monophosphate response element-binding protein at serine 133.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein phosphatase-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical review 123: Anabolic therapy for osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel cAMP-stimulated pathway in protein phosphatase 2A activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTH differentially regulates expression of RANKL and OPG.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOST is a target gene for PTH in bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commitment to the osteoblast lineage is not required for RANKL gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoporosis: impact on health and economics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKA-induced Receptor Activator of NF-κB Ligand (RANKL) Expression in Vascular Cells Mediates Osteoclastogenesis but Not Matrix Calcification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of protein phosphatase 2A Cα enhances bone formation and osteoblast differentiation through the expression of bone-specific transcription factor Osterix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone analogues in the treatment of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix-embedded cells control osteoclast formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteocyte RANKL: new insights into the control of bone remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A Cα is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone regulates histone deacetylase (HDAC) 4 through protein kinase A-mediated phosphorylation and dephosphorylation in osteoblastic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HDAC4 integrates PTH and sympathetic signaling in osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTH receptor-1 signalling-mechanistic insights and therapeutic prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIKs control osteocyte responses to parathyroid hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/30377251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.RA118.004751

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30377251%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30377251%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30377251%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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