Grb2 signaling in cell motility and cancer (Q58199697)

Europe PubMed Central

title

Grb2 signaling in cell motility and cancer (English)

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Alessio Giubellino

1

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ORCID Public Data File 2021

author name string

Terrence R Burke

series ordinal

2

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Donald P Bottaro

series ordinal

3

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language of work or name

English

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publication date

August 2008

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published in

Expert Opinion on Therapeutic Targets

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volume

12

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issue

8

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page(s)

1021-33

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cites work

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Investigation of cell cycle arrest effects of actinomycin D at G1 phase using proteomic methods in B104-1-1 cells

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8-O-Methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor

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Specificity and affinity motifs for Grb2 SH2-ligand interactions

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Characterization of the interaction of natural proline-rich peptides with five different SH3 domains.

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21 January 2018

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21 January 2018

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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes

21 January 2018

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High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia

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Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel

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UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug

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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

21 January 2018

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Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic

21 January 2018

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Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity

21 January 2018

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The role of Grb2-associated proteins in T-cell activation

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Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.

21 January 2018

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Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists

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Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling

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Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

30 November 2018

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Antagonists of the Src homology 2 (SH2) domains of Grb2, Src, Lck and ZAP-70.

30 November 2018

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Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

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SH3 domains: complexity in moderation

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The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

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A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity

30 November 2018

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Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins

30 November 2018

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Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

30 November 2018

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30 November 2018

HGF/SF in angiogenesis

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Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

30 November 2018

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Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells

30 November 2018

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

30 November 2018

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The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

30 November 2018

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

30 November 2018

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Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

30 November 2018

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Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens

30 November 2018

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12 December 2020

A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

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12 December 2020

Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs

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12 December 2020

Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain

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12 December 2020

Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines

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12 December 2020

Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands

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12 December 2020

Involvement of focal adhesion kinase in hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells

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12 December 2020

Overexpression of the Grb2 gene in human breast cancer cell lines

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12 December 2020

The Wiskott-Aldrich syndrome

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12 December 2020

Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes

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12 December 2020

Actinomycin D as a novel SH2 domain ligand inhibits Shc/Grb2 interaction in B104-1-1 (neu*-transformed NIH3T3) and SAA (hEGFR-overexpressed NIH3T3) cells

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12 December 2020

Structure-based design of a non-peptidic antagonist of the SH2 domain of GRB2

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12 December 2020