Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases (Q58214454)

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7 January 2020

title

Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases (English)

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7 January 2020

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3

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7 January 2020

Benedikt M. Kessler

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7 January 2020

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Hidde L Ploegh

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7 January 2020

2

Huib Ovaa

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7 January 2020

author name string

Anna Borodovsky

1

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7 January 2020

Emily S Venanzi

4

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7 January 2020

Matthew S Bogyo

5

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7 January 2020

Brian G Hekking

6

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7 January 2020

Herman S Overkleeft

9

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7 January 2020

publication date

1 February 2005

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7 January 2020

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7 January 2020

volume

6

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7 January 2020

issue

2

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7 January 2020

page(s)

287-291

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7 January 2020

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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A superfamily of protein tags: ubiquitin, SUMO and related modifiers

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SP-RING for SUMO: new functions bloom for a ubiquitin-like protein

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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

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A new NEDD8-ligating system for cullin-4A

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A protein conjugation system essential for autophagy

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Role of the Apg12 conjugation system in mammalian autophagy

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A family of mammalian F-box proteins

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Mechanisms underlying ubiquitination

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Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway

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Deubiquitinating enzymes as cellular regulators

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Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

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SUMO: ligases, isopeptidases and nuclear pores

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Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases

21 January 2018

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A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

21 January 2018

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UBPY: a growth-regulated human ubiquitin isopeptidase.

21 January 2018

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Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

21 January 2018

1 reference

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Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

21 January 2018

1 reference

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A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

21 January 2018

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Multiple associated proteins regulate proteasome structure and function

21 January 2018

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The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)

21 January 2018

1 reference

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Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T

21 January 2018

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FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development

21 January 2018

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BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

21 January 2018

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

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Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo

21 January 2018

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Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

21 January 2018

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Controlling apoptosis by inhibition of caspases

21 January 2018

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

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Proteasome inhibitors: from research tools to drug candidates

21 January 2018

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Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes

21 January 2018

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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

21 January 2018

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Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway

21 January 2018

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Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

21 January 2018

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Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition

21 January 2018

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Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity

21 January 2018

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Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution

21 January 2018

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

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Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

21 January 2018

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Solid support linker strategies

21 January 2018

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Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

21 January 2018

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Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CBIC.200400236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15651044%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference