CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions (Q59084697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions (English)

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4 April 2020

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2

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4 April 2020

Martin A.M. Reijns

3

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Michael Aregger

9

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Jason Moffat

18

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Tatjana Stankovic

22

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Andrew Jackson

23

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21

Johann de Bono

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4 April 2020

author name string

Michal Zimmermann

1

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4 April 2020

Angelo Agathanggelou

4

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Rachel Challis

5

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4 April 2020

Žygimantė Tarnauskaitė

6

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Morwenna Muir

7

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Adeline Fluteau

8

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Andrea McEwan

10

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Wei Yuan

11

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Matthew Clarke

12

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4 April 2020

Maryou B Lambros

13

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Shankara Paneesha

14

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Paul Moss

15

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4 April 2020

Megha Chandrashekhar

16

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Stephane Angers

17

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Valerie G Brunton

19

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Traver Hart

20

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Daniel Durocher

24

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language of work or name

English

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publication date

4 July 2018

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4 April 2020

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4 April 2020

volume

559

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issue

7713

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4 April 2020

page(s)

285-289

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describes a project that uses

4 April 2020

Cytoscape

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9 June 2022

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https://scigraph.springernature.com/pub.10.1038/s41586-018-0291-z

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Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks

30 November 2018

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30 November 2018

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Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

30 November 2018

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The Balancing Act of Ribonucleotides in DNA

30 November 2018

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30 November 2018

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TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

30 November 2018

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30 November 2018

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

30 November 2018

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30 November 2018

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30 November 2018

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MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

30 November 2018

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Easy quantitative assessment of genome editing by sequence trace decomposition

30 November 2018

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Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability

30 November 2018

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30 November 2018

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Improved vectors and genome-wide libraries for CRISPR screening

30 November 2018

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Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

30 November 2018

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Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

30 November 2018

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Genome engineering using the CRISPR-Cas9 system

30 November 2018

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IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

30 November 2018

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Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

30 November 2018

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Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA

30 November 2018

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RNase H2 roles in genome integrity revealed by unlinking its activities

30 November 2018

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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

30 November 2018

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PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

30 November 2018

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

30 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

30 November 2018

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Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

30 November 2018

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Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

30 November 2018

1 reference

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Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

30 November 2018

1 reference

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Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors

30 November 2018

1 reference

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The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

30 November 2018

1 reference

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Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems

30 November 2018

1 reference

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Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

30 November 2018

1 reference

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

30 November 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

10.1038/S41586-018-0291-Z

30 November 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

29973717

1 reference