Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing (Q59099426)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10318786%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing (English)

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7 December 2019

2

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7 December 2019

author name string

C A Saura

1

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7 December 2019

F Davenport

3

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7 December 2019

C L Harris

4

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7 December 2019

T Iwatsubo

5

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7 December 2019

G Thinakaran

6

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7 December 2019

language of work or name

English

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publication date

1 May 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10318786%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

7 December 2019

published in

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7 December 2019

volume

274

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7 December 2019

issue

20

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7 December 2019

page(s)

13818-13823

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

7 December 2019

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Amyloid, the presenilins and Alzheimer's disease

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

21 January 2018

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

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Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

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Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

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Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

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Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

21 January 2018

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Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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Evidence for phosphorylation and oligomeric assembly of presenilin 1.

21 January 2018

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

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Functional inactivation of genes by dominant negative mutations

21 January 2018

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The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly

21 January 2018

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Inhibition of Gonadotropin-Releasing Hormone Receptor Signaling by Expression of a Splice Variant of the Human Receptor

21 January 2018

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Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

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Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

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Protein topology of presenilin 1

21 January 2018

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Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

21 January 2018

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Subcellular distribution and turnover of presenilins in transfected cells

21 January 2018

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Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.20.13818

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10318786%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference