Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment (Q60947965)

Protein phosphatase 2 catalytic subunit alpha

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Protein phosphatase 3 catalytic subunit alpha

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peptidyl-serine dephosphorylation

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CREB regulated transcription coactivator 1

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CREB regulated transcription coactivator 3

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CREB regulated transcription coactivator 2

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author name string

Tim Sonntag

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Jelena Ostojić

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Joan M Vaughan

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James J Moresco

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Young-Sil Yoon

5

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John R Yates

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Marc Montminy

Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. Role of the autoinhibitory domain

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language of work or name

English

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publication date

19 December 2018

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volume

11

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page(s)

134-145

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cites work

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12 December 2020

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

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12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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12 December 2020

Transcriptional regulation by cyclic AMP.

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12 December 2020

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

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12 December 2020

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

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12 December 2020

Transcriptional regulation by the phosphorylation-dependent factor CREB

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12 December 2020

Physiological substrates of cAMP-dependent protein kinase

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12 December 2020

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

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12 December 2020

TORCs: transducers of regulated CREB activity

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12 December 2020

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

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12 December 2020

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

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12 December 2020

Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins

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12 December 2020

Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

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12 December 2020

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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12 December 2020

MAP kinase kinase kinases and innate immunity

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12 December 2020

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network

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12 December 2020

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

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12 December 2020

TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity

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12 December 2020

A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function

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12 December 2020

Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression

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12 December 2020

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

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12 December 2020

Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus

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12 December 2020

The Creb1 coactivator Crtc1 is required for energy balance and fertility

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12 December 2020

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

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12 December 2020

Serine/threonine phosphatases: mechanism through structure

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12 December 2020

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

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12 December 2020

Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists

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12 December 2020

Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver

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12 December 2020

Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.

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12 December 2020

Interaction of calcineurin with substrates and targeting proteins

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12 December 2020

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

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12 December 2020

CRTC3 links catecholamine signalling to energy balance

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12 December 2020

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

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12 December 2020

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

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12 December 2020

Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.

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12 December 2020

BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus

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12 December 2020

Adipogenesis: from stem cell to adipocyte

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12 December 2020

Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells

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12 December 2020

Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice.

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12 December 2020

β-Adrenoceptor Signaling Networks in Adipocytes for Recruiting Stored Fat and Energy Expenditure

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12 December 2020

Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus

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12 December 2020

Assembly of allosteric macromolecular switches: lessons from PKA

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12 December 2020

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

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12 December 2020

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

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12 December 2020

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

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12 December 2020

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

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12 December 2020

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors

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12 December 2020

CRTC2 is required for β-cell function and proliferation

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12 December 2020

Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.

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12 December 2020

The CRTC1-SIK1 pathway regulates entrainment of the circadian clock

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12 December 2020

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

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12 December 2020

Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes

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12 December 2020

α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes

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12 December 2020

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

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12 December 2020

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

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12 December 2020

Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory.

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12 December 2020

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

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12 December 2020

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

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12 December 2020

The Basic Biology of PP2A in Hematologic Cells and Malignancies

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12 December 2020

Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance

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12 December 2020

Adipose-Derived Stromal Vascular Fraction Cells: Update on Clinical Utility and Efficacy

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12 December 2020

Brown and Beige Fat: Physiological Roles beyond Heat Generation

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12 December 2020

Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases

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12 December 2020

PP2A as a master regulator of the cell cycle

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12 December 2020

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

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12 December 2020

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

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12 December 2020

UniProt: the universal protein knowledgebase

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12 December 2020

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

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12 December 2020

CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis

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12 December 2020

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).

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12 December 2020

cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis

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12 December 2020

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential

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12 December 2020

Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling

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12 December 2020