Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms (Q64051857)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

title

Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

Jennifer L Jakubowski

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

Daniel Groot

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

Ting Wang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

Viviane Labrie

9

1 reference

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27 April 2020

8

Arturas Petronis

1 reference

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27 April 2020

2

Lee Marshall

1 reference

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27 April 2020

author name string

Peipei Li

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

Gabriel Oh

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

Yu He

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

language of work or name

English

0 references

publication date

21 May 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

published in

Nature Communications

1 reference

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27 April 2020

volume

10

1 reference

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27 April 2020

issue

1

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27 April 2020

page(s)

2246

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describes a project that uses

27 April 2020

Cytoscape

1 reference

9 June 2022

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inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6529540

inferred from PubMed Central ID database lookup

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Neuropathological stageing of Alzheimer-related changes

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Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

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Alzheimer's disease is a synaptic failure

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Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.

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Enhanced Tau Aggregation in the Presence of Amyloid β.

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

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Recovery of learning and memory is associated with chromatin remodelling

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Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

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DNA methylation age of human tissues and cell types

1 reference

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7 January 2021

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning

1 reference

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7 January 2021

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease

1 reference

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7 January 2021

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

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7 January 2021

The transcriptional landscape of age in human peripheral blood

1 reference

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7 January 2021

Chromatin connectivity maps reveal dynamic promoter-enhancer long-range associations

1 reference

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7 January 2021

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers

1 reference

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7 January 2021

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

1 reference

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7 January 2021

Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity.

1 reference

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7 January 2021

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex

1 reference

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7 January 2021

Global epigenomic reconfiguration during mammalian brain development

1 reference

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7 January 2021

Genome-wide characterization of mammalian promoters with distal enhancer functions

1 reference

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7 January 2021

Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex.

1 reference

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7 January 2021

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

1 reference

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7 January 2021

Molecular biology of the Ets family of transcription factors

1 reference

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7 January 2021

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

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7 January 2021

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome.

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7 January 2021

Tau protein kinases: involvement in Alzheimer's disease

1 reference

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7 January 2021

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

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7 January 2021

Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer's disease brain tissue

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

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Human DNA methylomes at base resolution show widespread epigenomic differences

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Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States

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7 January 2021

Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease

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7 January 2021

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

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7 January 2021

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

1 reference

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7 January 2021

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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Neuronal cell cycle re-entry mediates Alzheimer disease-type changes

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Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer's Model

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Amyloid-β alters the DNA methylation status of cell-fate genes in an Alzheimer's disease model

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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

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BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

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PubMed

https://pubmed.ncbi.nlm.nih.gov/31113950

12 December 2020

inferred from PubMed ID database lookup

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/31113950

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-019-10101-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31113950%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

31113950

1 reference